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PMID: 4416771 Published · ppublish English Journal Article

Ultrastructural changes in livers of two patients with hypervitaminosis A.

The American journal of pathology ·Vol. 76 ·No. 3 ·1974-09-00 ·Pages 451-61

Hruban Z, Russell RM, Boyer JL, Glagov S, Bagheri SA

Abstract

The principal distinctive ultrastructural changes observed in the livers of 2 patients with chronic hypervitaminosis A were perisinusoidal fibrosis and massive accumulation of lipid-storing cells (Ito cells). The fibrosis consisted of a network of basement membranes with numerous bundles of collagen and reticulum fibrils. This network contained numerous Ito cells, and moderate numbers of lymphocytes, macrophoges and other mesenchymal cells. Impairment of blood flow by perisinusoidal fibrosis probably resulted in the secondary alterations in hepatocytes which included cellular atrophy and formation of cytoplasmic bullae.

MeSH Terms
Basement Membrane/pathology Biopsy, Needle Collagen Connective Tissue Cells Cytoplasm Female Fibroblasts Golgi Apparatus Humans Lipid Metabolism Liver/blood supply,drug effects,ultrastructure Liver Diseases/blood Lymphocytes Macrophages Male Microscopy, Electron Middle Aged Mitochondria, Liver Vitamin A/adverse effects
Chemicals
Vitamin A Collagen
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hruban Z
Russell R M
Boyer J L
Glagov S
Bagheri S A
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36 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1974-09-00
Pages
451-61
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1910880
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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