Regulation of hemoglobin synthesis. Effect of concentration of messenger ribonucleic acid, ribosome subunits, initiation factors, and salts on ratio of alpha and beta chains synthesized in vitro.

Amino Acyl-tRNA Synthetases/metabolism Animals Carbon Radioisotopes Centrifugation, Density Gradient Chromatography, DEAE-Cellulose Hemoglobins/biosynthesis Leucine/metabolism Magnesium/pharmacology Osmolar Concentration Peptide Chain Elongation, Translational Peptide Chain Initiation, Translational/drug effects Peptide Chain Termination, Translational Peptide Elongation Factors Peptide Initiation Factors Peptide Termination Factors Polyribosomes/drug effects,metabolism Potassium/pharmacology Protein Biosynthesis/drug effects Protein Precursors/biosynthesis RNA, Messenger/metabolism RNA, Transfer/metabolism Rabbits Reticulocytes/cytology,metabolism Ribosomes/drug effects,metabolism Spectrophotometry, Ultraviolet Tritium

Carbon Radioisotopes Hemoglobins Peptide Elongation Factors Peptide Initiation Factors Peptide Termination Factors Protein Precursors RNA, Messenger Tritium RNA, Transfer Amino Acyl-tRNA Synthetases Leucine Magnesium Potassium