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PMID: 4447616 Published · ppublish English Journal Article

Specific inhibition of the enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances.

The Biochemical journal ·Vol. 139 ·No. 2 ·1974-05-00 ·Pages 351-7

Corti A, Dave C, Williams-Ashman HG, Mihich E, Schenone A

Abstract

Methylglyoxal bis(guanylhydrazone) {1,1'-[(methylethanediylidene)-dinitrilo]diguanidine} is a very potent inhibitor of putrescine-activated S-adenosylmethionine decarboxylases from many different mammalian tissues, including sublines of mouse L1210 leukaemia that are resistant to the drug as well as sublines that are sensitive. The inhibition of purified rat ventral prostate S-adenosylmethionine decarboxylase is competitive with respect to the S-adenosylmethionine substrate, and is much greater in the presence than in the absence of the activator putrescine. Inhibition by the drug depends, among other things, on the nature of the aliphatic amines that can serve as stimulators of rat prostate S-adenosylmethionine decarboxylase. Effects of some congeners of methylglyoxal bis(guanylhydrazone) on the enzyme are described.

MeSH Terms
Amidines/pharmacology Animals Brain/enzymology Carboxy-Lyases/antagonists & inhibitors Cell Line Enzyme Inhibitors Female Glyoxal/analogs & derivatives,pharmacology Hydrazones/pharmacology Hydrogen-Ion Concentration Kidney/enzymology Leukemia L1210/enzymology Liver/enzymology Male Mice Myocardium/enzymology Prostate/enzymology Putrescine/metabolism Rats S-Adenosylmethionine/metabolism Salivary Glands/enzymology Spleen/enzymology Thymus Gland/enzymology
Chemicals
Amidines Enzyme Inhibitors Hydrazones Glyoxal S-Adenosylmethionine Carboxy-Lyases Putrescine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Corti A
Dave C
Williams-Ashman H G
Mihich E
Schenone A
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24 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1390351
Published
1974-05-00
Pages
351-7
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1166290
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1390351 PMC Full Text View journal details
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