T4 transfer RNAs: codon recognition and translational properties.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 5 ·1972-05-00 ·Pages 1114-8

Scherberg NH, Weiss SB

Abstract

T4 phage transfer RNAs recognize the previously assigned codons for a given amino acid; however, they tend to prefer code words that are less well recognized by their host. The phage transfer RNAs are more effective in polypeptide synthesis with T4 rather than Escherichia coli messenger RNAs.

MeSH Terms

Acylation Arginine/metabolism Coliphages/metabolism Genetic Code Glycine/metabolism Isoleucine/metabolism Leucine/metabolism Nucleic Acid Denaturation Peptide Biosynthesis Peptide Chain Initiation, Translational Polynucleotides/metabolism Protein Binding RNA, Bacterial/metabolism RNA, Transfer/metabolism RNA, Viral/metabolism Ribosomes/metabolism Templates, Genetic Tritium

Chemicals

Polynucleotides RNA, Bacterial RNA, Viral Isoleucine Tritium RNA, Transfer Arginine Leucine Glycine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Scherberg N H

Weiss S B

References (14)

14 references, click to expand

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In vitro synthesis of T4 lysozyme by suppression of amber mutations.
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Virology. 1968 Oct;36(2):212-22 PMID: 4879188
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Proc Natl Acad Sci U S A. 1969 Mar;62(3):892-8 PMID: 4895217
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Coding specificity of Escherichia coli leucine transfer ribonucleic acids and effect of bacteriophage T2 infection.
J Mol Biol. 1970 Sep 14;52(2):179-93 PMID: 4320938
Codon--anticodon pairing: the wobble hypothesis.
J Mol Biol. 1966 Aug;19(2):548-55 PMID: 5969078
Transfer RNA coded by the T4 bacteriophage genome.
Proc Natl Acad Sci U S A. 1968 Sep;61(1):114-21 PMID: 4880604
Selective translation of T4 template RNA by ribosomes from T4-infected Escherichia coli.
Proc Natl Acad Sci U S A. 1969 Sep;64(1):345-51 PMID: 4904642
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Amino acid acceptor activity of bacteriophage T4 transfer RNA.
FEBS Lett. 1968 Nov;2(1):39-41 PMID: 11946263
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.5.1114

Published

1972-05-00

Pages

1114-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426642

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.5.1114 PMC Full Text View journal details

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T4 transfer RNAs: codon recognition and translational properties.

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