Rabies vaccines and interferon.

The Journal of hygiene ·Vol. 70 ·No. 3 ·1972-09-00 ·Pages 445-53

Turner GS

Abstract

Samples of Fermi, Semple, modified Semple, Duck embryo and tissue culture rabies vaccine were inoculated by different routes and in different doses into rabbits, mice and hamsters. The vaccines induced neither detectable interferon nor immediate protection against lethal challenge with CVS rabies virus.Under similar conditions, high but transient levels of interferon were induced in control animals of the same species with the polynucleotide complex Poly I.C. Hamsters but not mice were protected by Poly I.C.-induced interferon.No autointerference by vaccine with challenge virus was established. Vaccine-induced protection in mice was directly related to immune response.

MeSH Terms

Animals Antibody Formation Cricetinae Culture Techniques Ducks/embryology Injections, Intraperitoneal Injections, Subcutaneous Interferons/biosynthesis,blood Mice Neutralization Tests Poly I-C/therapeutic use Rabbits Rabies/prevention & control Rabies Vaccines/administration & dosage Vaccination Viral Interference Viral Vaccines

Chemicals

Rabies Vaccines Viral Vaccines Interferons Poly I-C

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Turner G S

References (30)

30 references, click to expand

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Article Info

Journal

The Journal of hygiene

Abbr.

J Hyg (Lond)

ISSN

0022-1724

DOI

10.1017/s0022172400063026

Published

1972-09-00

Pages

445-53

Language

English

Region

England

NLM ID

0375374

PMCID

PMC2130208

Subset

External Links

PubMed source DOI: 10.1017/s0022172400063026 PMC Full Text View journal details

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