Biological activities of synthetic peptides corresponding to fragments of and to the entire sequence of the vasoactive intestinal peptide.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 2 ·1973-02-00 ·Pages 382-4

Bodanszky M, Klausner YS, Said SI

Abstract

An octacosapeptide with the entire sequence proposed for the newly isolated vasoactive intestinal polypeptide was synthesized and had the expected biological properties. Synthetic peptides corresponding to the C-terminal hendeca-, tetradeca-, pentadeca-, and docosapeptide sequences of the vasoactive intestinal polypeptide showed activities that increased with increasing chain length.

MeSH Terms

Amino Acid Sequence Animals Biological Assay Blood Pressure/drug effects Dogs Gastrointestinal Hormones/chemical synthesis,pharmacology Glucagon/analysis,pharmacology Guinea Pigs Intestine, Small/analysis Muscle, Smooth/drug effects Peptides/chemical synthesis,isolation & purification,pharmacology Rats Regional Blood Flow/drug effects Secretin/analysis,pharmacology Stomach/drug effects Trachea/drug effects Vasodilator Agents/chemical synthesis,pharmacology

Chemicals

Gastrointestinal Hormones Peptides Vasodilator Agents Secretin Glucagon

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bodanszky M

Klausner Y S

Said S I

References (5)

5 references, click to expand

Effects on smooth muscle preparations of unidentified vasoactiv peptides from intestine and lung.
Nature. 1970 Mar 21;225(5238):1144-6 PMID: 4392130
Polypeptide with broad biological activity: isolation from small intestine.
Science. 1970 Sep 18;169(3951):1217-8 PMID: 5450698
Structure of porcine secretin. The amino acid sequence.
Eur J Biochem. 1970 Sep;15(3):513-9 PMID: 5465996
A gastric inhibitory polypeptide. II. The complete amino acid sequence.
Can J Biochem. 1971 Aug;49(8):867-72 PMID: 5120249
Isolation from porcine-intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon.
Eur J Biochem. 1972 Jul 13;28(2):199-204 PMID: 5069712

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.70.2.382

Published

1973-02-00

Pages

382-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC433264

Subset

External Links

PubMed source DOI: 10.1073/pnas.70.2.382 PMC Full Text View journal details

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Biological activities of synthetic peptides corresponding to fragments of and to the entire sequence of the vasoactive intestinal peptide.

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