Home LiteratureArticle Details
PMID: 4514995 Published · ppublish English Journal Article

Immunoglobulin synthesis and secretion by cells in the mouse thymus that do not bear theta antigen.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 3 ·1973-03-00 ·Pages 834-8

Vitetta ES, Uhr JW, Boyse EA

Abstract

The mouse thymus contains cells that synthesize and secrete minute amounts of immunoglobulin (Ig). These cells were studied by a combination of cytotoxic tests (with alloantisera prepared in congenic strains of mice) followed by pulse labeling of the surviving cell population with [(3)H]tyrosine. The immunoglobulin-synthesizing cells constitute less than 2% of the total cell population and are theta(-), TL(-), Ly-B(-), Ig(+), H-2(+), and PC(+). Since this phenotype is not characteristic of cells of the thymocyte lineage, the Ig(+) cells are probably plasma cells and/or bone marrow-derived (B) lymphocytes. Similar studies of spleen cells indicate that immunoglobulin-synthesizing and secreting cells are theta(-).

MeSH Terms
Animals Antibody-Producing Cells/immunology Electrophoresis, Polyacrylamide Gel Immunoglobulins/analysis,biosynthesis Mice Spleen/cytology,immunology Thymus Gland/cytology,immunology Tritium
Chemicals
Immunoglobulins Tritium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vitetta E S
Uhr J W
Boyse E A
References (34)
34 references, click to expand
  1. The immunoglobulin nature of the antigen recognition site on cells mediating transplantation immunity and delayed hypersentivity.
    J Immunol. 1970 Mar;104(3):762-5 PMID: 4190976
  2. Immunoglobulins on the surface of thymus-derived cells engaged in the initiation of a humoral immune response.
    J Exp Med. 1971 Sep 1;134(3 Pt 1):618-29 PMID: 15776565
  3. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.
    Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93 PMID: 4385242
  4. Genetic control of specific immune responses.
    Adv Immunol. 1969;11:31-74 PMID: 4908392
  5. Antigen-binding lymphocytes in human fetal thymus.
    Lancet. 1970 Jun 6;1(7658):1199-202 PMID: 4192379
  6. Surface alloantigens of plasma cells.
    J Exp Med. 1970 Jun 1;131(6):1325-41 PMID: 5419273
  7. Thymus dependence of theta-bearing cells in the peripheral lymphoid tissues of mice.
    Immunology. 1970 Jun;18(6):931-42 PMID: 5428870
  8. Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence.
    Immunology. 1970 Oct;19(4):637-50 PMID: 4097588
  9. Antigen-binding cells in normal mouse thymus.
    Science. 1970 Dec 4;170(3962):1102-4 PMID: 4920186
  10. Hydrocortisne resistance of graft vs host activity in mouse thymus, spleen and bone marrow.
    J Immunol. 1970 Nov;105(5):1146-50 PMID: 4395187
  11. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization.
    J Exp Med. 1970 Oct 1;132(4):702-20 PMID: 4101362
  12. Suppression of graft versus host reaction by univalent anti-immunoglobulin antibody.
    Nat New Biol. 1971 Apr 21;230(16):248-50 PMID: 4396812
  13. Histocompatibility gene organization and mixed lymphocyte reaction.
    Nat New Biol. 1971 Apr 28;230(17):271-2 PMID: 5280666
  14. Specific inactivation of thymus-derived (T) and non-thymus-derived (B) lymphocytes by 125I-labelled antigen.
    Nat New Biol. 1971 May 26;231(21):104-6 PMID: 4103326
  15. Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse splenic lymphocytes.
    J Exp Med. 1971 Jul 1;134(1):242-64 PMID: 4104295
  16. Inhibition of human mixed lymphocyte reaction by antibodies to immunoglobulin light chain determinants.
    Clin Exp Immunol. 1971 Sep;9(3):313-28 PMID: 4105838
  17. Surface immunoglobulins on thymus and thymus-derived lymphoid cells.
    J Exp Med. 1971 Oct 1;134(4):1005-15 PMID: 5315413
  18. Immunoglobulin and other surface antigens of cells of the immune system.
    J Exp Med. 1971 Oct 1;134(4):815-32 PMID: 4106485
  19. Mixed leukocyte cultures and HL-A antigens. II. Inhibition by anti-HL-A sera.
    Transplant Proc. 1971 Mar;3(1):63-70 PMID: 4107669
  20. Cells mediating specific in vitro cytotoxicity. I. Detection of receptor-bearing lymphocytes.
    J Exp Med. 1971 Dec 1;134(6):1385-402 PMID: 5001703
  21. Antigenic change and cell maturation in murine thymocytes.
    Cell Immunol. 1970 Nov;1(5):536-44 PMID: 4943362
  22. Characteristics of the immunocompetent cells in the mouse thymus: cell population changes during cortisone-induced atrophy and subsequent regeneration.
    Cell Immunol. 1970 Nov;1(5):545-60 PMID: 4399790
  23. Specific binding of antigen to lymphocytes. Evidence for lack of unispecificity in antigen-binding cells.
    Am J Pathol. 1971 Nov;65(2):451-65 PMID: 5134892
  24. An ultrastructural study of lymphocytes with surface-bound immunoglobulin.
    J Exp Med. 1972 Feb 1;135(2):267-76 PMID: 4536751
  25. Quantitative features of a sandwich radioimmunolabeling technique for lymphocyte surface receptors.
    J Exp Med. 1972 Feb 1;135(2):405-28 PMID: 4110525
  26. Histoincompatibility attributable to genes near H-2 that are not revealed by hemagglutination or cytotoxicity tests.
    Transplantation. 1972 Apr;13(4):431-2 PMID: 4552366
  27. Isolation and partial characterization of lymphocyte surface immunoglobulins.
    J Exp Med. 1972 Apr 1;135(4):956-71 PMID: 4111775
  28. Isolation of surface immunoglobulin from lymphocytes from human and murine thymus.
    Nat New Biol. 1972 Feb 23;235(60):240-2 PMID: 4502413
  29. Evidence for surface-associated immunoglobulin on T and B lymphocytes.
    Eur J Immunol. 1971 Dec;1(6):447-52 PMID: 4947881
  30. T and B rosette-forming cells.
    Eur J Immunol. 1971 Dec;1(6):501-3 PMID: 5317028
  31. Specificity and nature of the antigen-combining sites on fetal and mature thymus lymphocytes.
    J Immunol. 1972 May;108(5):1439-46 PMID: 4112926
  32. Cell surface immunoglobulin. IV. Distribution among thymocytes, bone mrrow cells, and their derived populations.
    J Exp Med. 1972 Jul 1;136(1):81-93 PMID: 5064226
  33. Cell surface immunoglobulin. V. Release from murine splenic lymphocytes.
    J Exp Med. 1972 Oct 1;136(4):676-96 PMID: 5056670
  34. Thymus-derived lymphocytes: their distribution and role in the development of peripheral lymphoid tissues of the mouse.
    Eur J Immunol. 1971 Jan;1(1):27-30 PMID: 14978858
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.3.834
Published
1973-03-00
Pages
834-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433370
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.3.834 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2