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PMID: 4517933 Published · ppublish English Journal Article

Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 10 ·1973-10-00 ·Pages 2785-8

Lindahl P, Leary P, Gresser I

Abstract

Preparations of mouse interferon enhanced the expression of surface antigens of murine leukemia L 1210 cells, as determined by their alloantibody-absorbing capacity. The factor responsible for the enhancement of surface antigen expression could not be dissociated from the antiviral activity of interferon by standard physicochemical means. Likewise, interferon did not increase the antibody-absorbing capacity of an interferon-resistant subline of L 1210 cells. We conclude that interferon treatment of L 1210 cells is accompanied by modifications of the cell surface.

MeSH Terms
Animals Antigen-Antibody Reactions/drug effects Antigens, Neoplasm/analysis Cell Membrane/immunology Cells, Cultured Chromium Radioisotopes Cytotoxicity Tests, Immunologic Interferons/pharmacology Isoantibodies Kinetics Leukemia L1210/immunology Mice Mice, Inbred C57BL/immunology Mice, Inbred DBA/immunology
Chemicals
Antigens, Neoplasm Chromium Radioisotopes Isoantibodies Interferons
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lindahl P
Leary P
Gresser I
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.10.2785
Published
1973-10-00
Pages
2785-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC427109
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.10.2785 PMC Full Text View journal details
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