Interspersion of repetitive and single-copy sequences in nuclear ribonucleic acid of high molecular weight.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 4 ·1974-04-00 ·Pages 1108-12

Holmes DS, Bonner J

Abstract

Nuclear RNA of high molecular weight, approximately 15 to 30 x 10(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were interspersed within the same molecule. The present communication distinguishes between these possibilities and shows that a large proportion of nuclear RNA of high molecular weight consists of interspersed middle repetitive and single-copy sequences.

MeSH Terms

Animals Base Sequence Cell Line Cell Nucleus/analysis Cricetinae Molecular Weight Nucleic Acid Hybridization Nucleotides/analysis RNA/analysis,metabolism RNA, Neoplasm/analysis RNA, Ribosomal/metabolism Rats Ribonucleases/metabolism Transcription, Genetic Tritium

Chemicals

Nucleotides RNA, Neoplasm RNA, Ribosomal Tritium RNA Ribonucleases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Holmes D S

Bonner J

References (16)

16 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.71.4.1108

Published

1974-04-00

Pages

1108-12

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388172

Subset

External Links

PubMed source DOI: 10.1073/pnas.71.4.1108 PMC Full Text View journal details

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Interspersion of repetitive and single-copy sequences in nuclear ribonucleic acid of high molecular weight.

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