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PMID: 4536745 Published · ppublish English Journal Article

On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 2 ·1972-02-00 ·Pages 343-7

Christenson JG, Dairman W, Udenfriend S

Abstract

Simultaneous immunological titration of DOPA and 5-hydroxytryptophan decarboxylase activities, from a number of tissues of various species, showed that the two activities were not distinguishable with a monospecific antiserum to hog kidney decarboxylase. Together with previous findings, these data firmly establish the concept that in mammalian tissues the two enzyme activities are associated with a single protein, namely aromatic L-amino acid decarboxylase.

MeSH Terms
5-Hydroxytryptophan Animals Brain/enzymology Carboxy-Lyases/metabolism Decarboxylation Dopa Decarboxylase/metabolism Female Goats Immune Sera Immunochemistry Kidney/enzymology Liver/enzymology Pineal Gland/enzymology Rabbits Rats Rats, Inbred Strains Solubility Species Specificity Swine Time Factors
Chemicals
Immune Sera 5-Hydroxytryptophan Carboxy-Lyases Dopa Decarboxylase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Christenson J G
Dairman W
Udenfriend S
References (22)
22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.2.343
Published
1972-02-00
Pages
343-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC426454
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.2.343 PMC Full Text View journal details
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