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PMID: 4537952 Published · ppublish English Journal Article

Genetic variants of von Willebrand's disease.

British medical journal ·Vol. 3 ·No. 5822 ·1972-08-05 ·Pages 317-20

Holmberg L, Nilsson IM

Abstract

A specific antiserum against an antihaemophilic factor (AHF)-related plasma protein was raised in rabbits. A quantitative immunochemical method was used to determine the amount of this protein present in the plasma of 33 patients with haemophilia A and 70 patients with von Willebrand's disease. The protein probably consisted of AHF residing in or complexed with the von Willebrand factor. The patients with von Willebrand's disease were shown to fall into two separate genetic groups, one with decreased and one with normal amounts of the AHF-related protein. The patients with haemophilia A had normal amounts of the protein in their plasma.

MeSH Terms
Animals Blood Coagulation Tests Factor VIII Female Genes, Dominant Hemophilia A Humans Immune Sera Male Pedigree Platelet Adhesiveness Rabbits/immunology Sex Chromosomes von Willebrand Diseases/genetics
Chemicals
Immune Sera Factor VIII
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Holmberg L
Nilsson I M
References (19)
19 references, click to expand
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Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.3.5822.317
Published
1972-08-05
Pages
317-20
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1785514
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.3.5822.317 PMC Full Text
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