Growth of Newcastle disease virus and rubella virus in rheumatoid and nonrehumatoid synovial cell cultures.

Infection and immunity ·Vol. 6 ·No. 3 ·1972-09-00 ·Pages 326-9

Spruance SL, Smith CB, Krall J, Ward JR

Abstract

Rheumatoid and nonrheumatoid synovial cell cultures were challenged with Newcastle disease virus and rubella virus in an attempt to confirm reports that rheumatoid synovial cells are relatively resistant to infection with these viruses. Newcastle disease virus caused complete cell destruction by day 7 in both rheumatoid and nonrheumatoid cultures, and peak virus titers were similar. Rubella virus replicated in both rheumatoid and nonrheumatoid synovial cell cultures, and no consistent differences in virus titers were detected. Rubella-infected cell lines were observed for up to 28 days and no virus-specific cytopathic effect was seen.

MeSH Terms

Adolescent Adult Aged Cells, Cultured Cytopathogenic Effect, Viral Female Humans Hyaluronic Acid/analysis Hyaluronoglucosaminidase/analysis Infant, Newborn Male Middle Aged Newcastle disease virus/growth & development Rheumatic Diseases/microbiology Rubella virus/growth & development Synovial Fluid/analysis,enzymology,microbiology Time Factors Virus Cultivation Virus Replication

Chemicals

Hyaluronic Acid Hyaluronoglucosaminidase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Spruance S L

Smith C B

Krall J

Ward J R

References (8)

8 references, click to expand

Use of "synovial" cell cultures in the search for virus in rheumatoid arthritis.
Arthritis Rheum. 1965 Dec;8(6):1047-52 PMID: 5884815
Rubella virus carrier cultures derived from congenitally infected infants.
J Exp Med. 1966 May 1;123(5):795-816 PMID: 5938814
Evidence for an infectious etiology of rheumatoid arthritis.
Med Clin North Am. 1968 May;52(3):673-6 PMID: 4968251
Rubella infection of synovial cells and the resistance of cells derived from patients with rheumatoid arthritis.
J Exp Med. 1970 Feb;131(2):367-75 PMID: 5419855
Replication of rubella, Newcastle disease, and vesicular stomatitis viruses in cultured rheumatoid synovial cells.
Proc Soc Exp Biol Med. 1971 Nov;138(2):748-52 PMID: 4330239
Growth of rubella virus in cultures of synovial cells from rheumatoid arthritis.
Arthritis Rheum. 1972 Jan-Feb;15(1):85-8 PMID: 5059644
Composition and function of human synovial connective tissue cells measured in vitro.
J Lab Clin Med. 1961 Mar;57:394-407 PMID: 13691460
STUDIES OF RUBELLA. I. PROPERTIES OF THE VIRUS.
J Immunol. 1964 Oct;93:595-607 PMID: 14219075

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.6.3.326-329.1972

Published

1972-09-00

Pages

326-9

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422535

Subset

External Links

PubMed source DOI: 10.1128/iai.6.3.326-329.1972 PMC Full Text View journal details

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Growth of Newcastle disease virus and rubella virus in rheumatoid and nonrehumatoid synovial cell cultures.

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