Home LiteratureArticle Details
PMID: 4544817 Published · ppublish English Journal Article

T and B lymphocytes: striking differences in surface membranes.

British medical journal ·Vol. 1 ·No. 5904 ·1974-03-02 ·Pages 360-2

Mehrishi JN, Zeiller K

Abstract

Lymphocytes can be separated by electrophoresis into cells of high and of low electrophoretic mobility. Cells of high mobility are T cells and those of low mobility are B cells, with distinct immunological functions. Biophysical and biochemical studies on physically isolated and immunologically defined T and B cells in CBA mice showed striking differences in the chemical composition of the surface membranes.

MeSH Terms
Animals B-Lymphocytes Cell Membrane Electrophoresis Membrane Potentials Methods Mice Neuraminidase Phosphates/analysis Ribonucleases T-Lymphocytes
Chemicals
Phosphates Ribonucleases Neuraminidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mehrishi J N
Zeiller K
References (16)
16 references, click to expand
  1. Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.
    Cancer Res. 1968 Jul;28(7):1300-10 PMID: 4174339
  2. The mechanism of phytohemagglutinin (PHA) action. II. The effect of certain enzymes and sugars.
    Exp Cell Res. 1969 Apr;55(1):81-4 PMID: 5780796
  3. [On the separation and characterization of immunocompeent cells, using free flow continuous electrophoresis].
    Hoppe Seylers Z Physiol Chem. 1969 Apr;350(4):467-72 PMID: 5798590
  4. Effect of lysine polypeptides on the surface charge of normal and cancer cells.
    Eur J Cancer. 1969 Nov;5(5):427-35 PMID: 5366972
  5. Decreased phytohemagglutinin receptor sites in chronic lymphocytic leukemia.
    Biochim Biophys Acta. 1969 Dec 30;192(3):542-5 PMID: 5368257
  6. Cell surface localized IgM-kappa immunoglobulin reactivity in a case of chronic lymphocytic leukaemia.
    Clin Exp Immunol. 1970 Mar;6(3):421-8 PMID: 4191826
  7. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia.
    J Clin Invest. 1971 Nov;50(11):2368-75 PMID: 4999540
  8. Identification of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukaemia.
    Lancet. 1971 Oct 9;2(7728):788-91 PMID: 4106607
  9. Free flow electrophoretic separation of T and B lymphocytes. Evidence for various subpopulations of B cells.
    Hoppe Seylers Z Physiol Chem. 1972 Jan;353(1):105-10 PMID: 5016227
  10. The interactions of mitogens with lymphoid cells and the effect of neuraminidase on the cells' responsiveness to stimulation.
    Cell Immunol. 1972 Apr;3(4):590-605 PMID: 4554088
  11. Intramembraneous marker in T lymphocytes.
    Nat New Biol. 1972 Sep 27;239(91):112-4 PMID: 4538744
  12. Separation of T and B lymphocytes by preparative cell electrophoresis.
    Eur J Immunol. 1972 Oct;2(5):405-10 PMID: 4404386
  13. Regulation of normal and leukaemic lymphocyte transformation and recirculation by sodium periodate oxidation and sodium borohydride reduction.
    Nat New Biol. 1972 Dec 20;240(103):252-5 PMID: 4345244
  14. Evidence for transformation of human B lymphocytes by PHA.
    Nat New Biol. 1973 Feb 21;241(112):254-6 PMID: 4121653
  15. Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers.
    Nature. 1974 Jan 25;247(5438):213-5 PMID: 4589574
  16. SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.
    Lancet. 1964 Feb 29;1(7331):468-9 PMID: 14102250
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
Published
1974-03-02
Pages
360-2
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1633600
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]