Clonal memory. I. Time-course of proliferation of B-memory cells.

The Journal of experimental medicine ·Vol. 139 ·No. 5 ·1974-05-01 ·Pages 1361-7

McMichael AJ, Williamson AR

Abstract

A single clone of B cells producing anti-DNP antibody recognizable by the isoelectric-focusing spectrum has been used, in a double transfer system, to study clonal memory. Trasnsferable B memory develops between 4 and 7 days after the first transfer with antigen. B-memory cells thus proliferate before or concomitantly with antibody-forming cells.

MeSH Terms

Animals Antibodies/analysis Antibody Formation Antigens Autoradiography B-Lymphocytes/immunology Cell Division Clone Cells/immunology Dinitrophenols Female Immunization, Passive Immunologic Memory Iodine Radioisotopes Isoelectric Focusing Kinetics Mice Mice, Inbred CBA Radiation Chimera

Chemicals

Antibodies Antigens Dinitrophenols Iodine Radioisotopes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

McMichael A J

Williamson A R

References (10)

10 references, click to expand

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The X-Y-Z scheme of immunocyte maturation. IV. The exhaustion of memory cells.
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Proc Natl Acad Sci U S A. 1968 Jan;59(1):296-303 PMID: 4873344
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J Exp Med. 1970 Nov;132(5):1019-34 PMID: 4097133
Selection of a single antibody-forming cell clone and its propagation in syngeneic mice.
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1398-403 PMID: 5274467
Cell surveillance model for lymphocyte cooperation.
Nature. 1971 Dec 24;234(5330):454-6 PMID: 4944187
The asynchronous development of immunological memory in helper (T) and precursor (B) cell lines.
Eur J Immunol. 1971 Dec;1(6):413-21 PMID: 4947878
Factors affecting the propagation of a B cell clone forming antibody to the 2,4-dinitrophenyl group.
Eur J Immunol. 1972 Dec;2(6):487-93 PMID: 4120275
Amplification of B cell clones forming antibody to the 2,4-dinitrophenyl group.
Eur J Immunol. 1972 Dec;2(6):494-8 PMID: 4569995
Antigenic markers on mouse lymphoid cells: origin of cells mediating immunologic memory.
Cell Immunol. 1973 Mar;6(3):407-19 PMID: 4570684

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.139.5.1361

Published

1974-05-01

Pages

1361-7

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139665

Subset

External Links

PubMed source DOI: 10.1084/jem.139.5.1361 PMC Full Text View journal details

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Clonal memory. I. Time-course of proliferation of B-memory cells.

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