Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 4 ·1974-04-00 ·Pages 1474-8

Basch RS, Goldstein G

Abstract

Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.

MeSH Terms

Animals Antibodies Antibody Specificity Antigens Bone Marrow/immunology Bone Marrow Cells Cell Differentiation/drug effects Cytotoxicity Tests, Immunologic Hormones/pharmacology Immune Sera In Vitro Techniques Mice Mice, Inbred Strains Peptides/pharmacology T-Lymphocytes/drug effects,immunology Thymus Extracts/pharmacology Thymus Gland/immunology

Chemicals

Antibodies Antigens Hormones Immune Sera Peptides Thymus Extracts

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Basch R S

Goldstein G

References (21)

21 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.71.4.1474

Published

1974-04-00

Pages

1474-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388252

Subset

External Links

PubMed source DOI: 10.1073/pnas.71.4.1474 PMC Full Text View journal details

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Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.

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