Immunity to murine sarcoma virus induced tumours. 3. Analysis of the cell populations involved in protection from lethal tumour progression of sublethally irradiated, MSV inoculated, mice.

British journal of cancer ·Vol. 30 ·No. 2 ·1974-08-00 ·Pages 118-28

Gorczynski RM, Norbury C

Abstract

A comparison was made between the cells responsible for demonstrable activity against MSV antigens, using both in vivo and in vitro assays. Similar cells (in terms of size and sensitivity to anti-theta serum) were detected in both assays. However, while lymphoid cells from animals at all stages post-MSV infection were active in protecting irradiated mice from the lethal effect of induction of MSV sarcomata, cells from animals at early stages post-MSV infection (when the tumour was in a progressive phase of growth) were not active in the in vitro assay. By manipulation of the in vivo assay conditions a situation was observed in which cells from "progressor animals" were able to suppress both the in vitro and in vivo activity of regressor lymphoid cells. The potential physiological role of this cell type is disussed.

MeSH Terms

Animals Antibodies, Anti-Idiotypic Antigens, Viral Antilymphocyte Serum Cell Count Cell Separation Centrifugation, Density Gradient Cobalt Radioisotopes Complement System Proteins Immune Sera Immunity, Cellular/radiation effects Immunoglobulins Lymphocytes/radiation effects Male Mice Mice, Inbred BALB C Protein Biosynthesis Radiation Effects Sarcoma, Experimental/immunology Spleen/cytology T-Lymphocytes/immunology

Chemicals

Antibodies, Anti-Idiotypic Antigens, Viral Antilymphocyte Serum Cobalt Radioisotopes Immune Sera Immunoglobulins Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gorczynski R M

Norbury C

References (20)

20 references, click to expand

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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1974.122

Published

1974-08-00

Pages

118-28

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2009265

Subset

External Links

PubMed source DOI: 10.1038/bjc.1974.122 PMC Full Text View journal details

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Immunity to murine sarcoma virus induced tumours. 3. Analysis of the cell populations involved in protection from lethal tumour progression of sublethally irradiated, MSV inoculated, mice.

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