Interactions of edeine with bacterial ribosomal subunits. Selective inhibition of aminoacyl-tRNA binding sites.

Alanine Anti-Bacterial Agents/metabolism,pharmacology Bacterial Proteins/biosynthesis Binding Sites Carbon Isotopes Coliphages Escherichia coli/metabolism Methionine Peptide Chain Initiation, Translational/drug effects Peptides/metabolism,pharmacology Phenylalanine Polynucleotides RNA, Bacterial/metabolism RNA, Messenger/metabolism RNA, Transfer/metabolism RNA, Viral Ribosomes/drug effects,metabolism Structure-Activity Relationship Tritium Ultracentrifugation

Anti-Bacterial Agents Bacterial Proteins Carbon Isotopes Peptides Polynucleotides RNA, Bacterial RNA, Messenger RNA, Viral Tritium Phenylalanine RNA, Transfer Methionine Alanine