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PMID: 4552987 Published · ppublish English Journal Article

Stimulation of unbalanced ribonucleic acid synthesis in Escherichia coli by methanol.

Journal of bacteriology ·Vol. 110 ·No. 1 ·1972-04-00 ·Pages 179-85

Javor GT

Abstract

Addition of methanol to a stringent strain of Escherichia coli, starving of methionine, stimulates unbalanced ribonucleic acid (RNA) synthesis. The newly formed RNA and ribonucleoprotein species sediment between 4S and 30S. As a result of methanol treatment, cells become permeable to actinomycin D. Damage to cellular membrane appears to influence the control for RNA synthesis.

MeSH Terms
Bacterial Proteins/biosynthesis Carbon Isotopes Cell Membrane Permeability/drug effects Cell Survival Centrifugation, Density Gradient Colorimetry Culture Media Dactinomycin/metabolism,pharmacology Escherichia coli/drug effects,metabolism Genetics, Microbial Kinetics Leucine/metabolism Methanol/pharmacology Methionine Mutation Nucleoproteins/biosynthesis RNA, Bacterial/biosynthesis Uracil/metabolism
Chemicals
Bacterial Proteins Carbon Isotopes Culture Media Nucleoproteins RNA, Bacterial Dactinomycin Uracil Methionine Leucine Methanol
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Javor G T
References (25)
25 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.110.1.179-185.1972
Published
1972-04-00
Pages
179-85
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC247396
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.110.1.179-185.1972 PMC Full Text View journal details
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