Studies on Escherichia coli enzymes involved in the synthesis of uridine diphosphate-N-acetyl-muramyl-pentapeptide.

Journal of bacteriology ·Vol. 110 ·No. 1 ·1972-04-00 ·Pages 26-34

Lugtenberg EJ

Abstract

The specific activities of l-alanine:d-alanine racemase, d-alanine:d-alanine ligase, and the l-alanine, d-glutamic acid, meso-diaminopimelic acid, and d-alanyl-d-alanine adding enzymes were followed during growth of Escherichia coli. The specific activities were nearly independent of the growth phase. d-Alanine:d-alanine ligase was inhibited by d-alanyl-d-alanine, d-cycloserine, glycine, and glycyl-glycine. l-Alanine:d-alanine racemase was found to be sensitive to d-cycloserine, glycine, and glycyl-glycine. The l-alanine adding enzyme was inhibited by glycine and glycyl-glycine.

MeSH Terms

Acetates Alanine Amino Acids Carbon Isotopes Chromatography, Paper Cycloserine Dipeptides Escherichia coli/enzymology,growth & development Genetics, Microbial Glucosamine Glutamates Glycine Isomerases/antagonists & inhibitors Kinetics Ligases/antagonists & inhibitors Mutation Nucleoside Diphosphate Sugars Peptidoglycan/biosynthesis Pimelic Acids Temperature Uracil Nucleotides

Chemicals

Acetates Amino Acids Carbon Isotopes Dipeptides Glutamates Nucleoside Diphosphate Sugars Peptidoglycan Pimelic Acids Uracil Nucleotides Cycloserine Isomerases Ligases Glucosamine Alanine Glycine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lugtenberg E J

References (16)

16 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.110.1.26-34.1972

Published

1972-04-00

Pages

26-34

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC247374

Subset

External Links

PubMed source DOI: 10.1128/jb.110.1.26-34.1972 PMC Full Text View journal details

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Studies on Escherichia coli enzymes involved in the synthesis of uridine diphosphate-N-acetyl-muramyl-pentapeptide.

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