Inhibition of macrophage response to brain injury. A new effect of pertussis vaccine possibly related to histamine-sensitizing factor.

The American journal of pathology ·Vol. 67 ·No. 2 ·1972-05-00 ·Pages 349-60

Levine S, Sowinski R

Abstract

Intravenous injection of pertussis vaccine inhibited the outpouring of macrophages into a zone of thermal coagulation necrosis in the brain. The inhibition of this cellular reaction to injury was observed in rats and mice, and was especially notable in gerbils. It was not due to nonspecific stress or to endotoxin. A relationship of this new activity to pertussis vaccine's histamine-sensitizing factor was suggested by the use of partially purified extracts and heat-inactivated vaccines. There was a close parallel between the effects of pertussis vaccine on brain macrophages and on the spleen.

MeSH Terms

Animals Brain Injuries/physiopathology Cell Movement/drug effects Cerebral Cortex/pathology Depression, Chemical Electric Injuries/physiopathology Endotoxins Escherichia coli Histamine/toxicity Hot Temperature Macrophages/drug effects Male Necrosis Pertussis Vaccine Rats Spleen/drug effects Splenomegaly/chemically induced

Chemicals

Endotoxins Pertussis Vaccine Histamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Levine S

Sowinski R

References (14)

14 references, click to expand

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Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1972-05-00

Pages

349-60

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC2032600

Subset

External Links

PubMed source PMC Full Text View journal details

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Inhibition of macrophage response to brain injury. A new effect of pertussis vaccine possibly related to histamine-sensitizing factor.

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