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PMID: 4559467 Published · ppublish English Journal Article Review

Acute pancreatitis.

California medicine ·Vol. 117 ·No. 2 ·1972-08-00 ·Pages 25-39

Geokas MC

Abstract

FOR MANY DECADES TWO TYPES OF ACUTE PANCREATITIS HAVE BEEN RECOGNIZED: the edematous or interstitial and the hemorrhagic or necrotic. In most cases acute pancreatitis is associated with alcoholism or biliary tract disease. Elevated serum or urinary alpha-amylase is the most important finding in diagnosis. The presence of methemalbumin in serum and in peritoneal or pleural fluid supports the diagnosis of the hemorrhagic form of the disease in patients with a history and enzyme studies suggestive of pancreatitis. There is no characteristic clinical picture in acute pancreatitis, and its complications are legion. Pancreatic pseudocyst is probably the most common and pancreatic abscess is the most serious complication. The pathogenetic principle is autodigestion, but the precise sequence of biochemical events is unclear, especially the mode of trypsinogen activation and the role of lysosomal hydrolases. A host of metabolic derangements have been identified in acute pancreatitis, involving lipid, glucose, calcium and magnesium metabolism and changes of the blood clotting mechanism, to name but a few. Medical treatment includes intestinal decompression, analgesics, correction of hypovolemia and other supportive and protective measures. Surgical exploration is advisable in selected cases, when the diagnosis is in doubt, and is considered imperative in the presence of certain complications, especially pancreatic abscess.

MeSH Terms
Acute Disease Alcoholism/complications Biliary Tract Diseases/complications Blood Coagulation Disorders/etiology Calcium/metabolism Diabetes Mellitus/etiology Diagnosis, Differential Female Humans Hypercalcemia/complications Hyperlipidemias/complications Lipid Metabolism Pancreatitis/chemically induced,diagnosis,etiology,genetics,metabolism,surgery,therapy Postoperative Complications Pregnancy Pregnancy Complications, Infectious
Chemicals
Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Geokas M C
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Article Info
Journal
California medicine
Abbr.
Calif Med
ISSN
0008-1264
Published
1972-08-00
Pages
25-39
Language
English
Region
United States
NLM ID
0410260
PMCID
PMC1518611
Subset
IM
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