Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin.

Animals Colchicine/pharmacology Cytoplasmic Granules/physiology Deuterium Glucose/antagonists & inhibitors,pharmacology In Vitro Techniques Insulin/metabolism Insulin Secretion Islets of Langerhans/cytology,drug effects,metabolism,physiology Male Methods Microtubules/physiology Perfusion Rats Secretory Rate/drug effects Time Factors Tolbutamide/pharmacology Vinblastine/pharmacology

Insulin Vinblastine Tolbutamide Deuterium Glucose Colchicine