Detection of delayed hypersensitivity in mice injected with ribonucleic acid-protein fractions of Salmonella typhimurium.

Infection and immunity ·Vol. 6 ·No. 3 ·1972-09-00 ·Pages 384-9

Smith RA, Bigley NJ

Abstract

Manifestations of delayed hypersensitivity (cell-mediated immunity) were found to be present in mice immunized with virulent Salmonella typhimurium SR-11 subfractions which contained appreciable concentrations of bacterial protein and in mice immunized with the living, attenuated RIA strain of S. typhimurium. Delayed hypersensitive responses were measured by footpad sensitivity in the immunized mice and in vitro by inhibition of spleen cell migration and by increase in (3)H-thymidine uptake by lymphoid cell populations when exposed to bacterial fractions rich in protein content.

MeSH Terms

Animals Antigens, Bacterial/pharmacology Bacterial Proteins/pharmacology Cell Migration Inhibition Cells, Cultured Exudates and Transudates/drug effects Female Foot Hypersensitivity, Delayed/immunology Immunity/drug effects Lymphoid Tissue Macrophages/drug effects Mice Mice, Inbred ICR Peritoneum/drug effects RNA, Bacterial/pharmacology Salmonella typhimurium/immunology Spleen/drug effects Thymidine Time Factors Tritium Vaccines, Attenuated/administration & dosage

Chemicals

Antigens, Bacterial Bacterial Proteins RNA, Bacterial Vaccines, Attenuated Tritium Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Smith R A

Bigley N J

References (16)

16 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.6.3.384-389.1972

Published

1972-09-00

Pages

384-9

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422545

Subset

External Links

PubMed source DOI: 10.1128/iai.6.3.384-389.1972 PMC Full Text View journal details

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Detection of delayed hypersensitivity in mice injected with ribonucleic acid-protein fractions of Salmonella typhimurium.

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