Iron metabolism in Hodgkin's disease.

British journal of cancer ·Vol. 26 ·No. 6 ·1972-12-00 ·Pages 444-52

Beamish MR, Jones PA, Trevett D, Evans IH, Jacobs A

Abstract

An evaluation of iron metabolism has been carried out in 23 untreated patients with Hodgkin's disease and 6 patients with other lymphomata. The reduction in red cell life span is related to the stage of the disease. There is an almost universal impairment of iron release from the reticuloendothelial system with a consequent sideropenia and failure of iron delivery to the bone marrow for erythropoiesis. This defect is found in all stages of the disease and is not related to systemic symptoms.

MeSH Terms

Bone Marrow/metabolism Chromium Isotopes Erythrocyte Aging Erythropoiesis Female Hemoglobins/analysis Hodgkin Disease/metabolism Humans Iron/blood,metabolism Iron Isotopes Lymphoma, Follicular/metabolism Lymphoma, Large B-Cell, Diffuse/metabolism Lymphoma, Non-Hodgkin/metabolism Male Metabolic Clearance Rate Mononuclear Phagocyte System/metabolism Transferrin/metabolism

Chemicals

Chromium Isotopes Hemoglobins Iron Isotopes Transferrin Iron

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Beamish M R

Jones P A

Trevett D

Evans I H

Jacobs A

References (12)

12 references, click to expand

The measurement of reticuloendothelial iron release using iron-dextran.
Br J Haematol. 1971 Dec;21(6):617-22 PMID: 5132947
Reutilization of iron in anemia complicating malignant neoplasma.
Blood. 1963 Jul;22:73-81 PMID: 13961012
The effect of inflammation on the utilization of erythrocyte and transferrin bound radioiron for red cell production.
Blood. 1957 Nov;12(11):972-83 PMID: 13471662
The mechanism of the anemia associated with Hodgkin's disease.
Blood. 1959 Jul;14(7):856-69 PMID: 13662329
Anemia in Hodgkin's disease.
Cancer. 1963 Apr;16:526-32 PMID: 14021759
A clinical study in Hodgkin's disease.
AMA Arch Intern Med. 1957 Apr;99(4):519-35 PMID: 13410157
The preparation of 59 Fe-labelled transferrin for ferrokinetic studies.
J Clin Pathol. 1971 Jul;24(5):472-4 PMID: 5571840
[Disorders of the utilization of hemoglobin iron during the developent of Hodgkin's disease].
Nouv Rev Fr Hematol. 1967 Sep-Oct;7(5):739-54 PMID: 4230113
METHOD FOR THE AUTOMATIC DETERMINATION OF SERUM IRON.
J Clin Pathol. 1965 Jan;18:98-102 PMID: 14247712
Characteristics of iron dextran utilization in man.
Blood. 1969 Sep;34(3):357-75 PMID: 5804025
An improved method for the simultaneous determination of iron-55 and iron-59 in blood by liquid scintillation counting.
Int J Appl Radiat Isot. 1966 Jul;17(7):391-7 PMID: 5967690
HAEMOLYTIC ANAEMIA IN HODGKIN'S DISEASE ASSOCIATED WITH IMMUNOGLOBULIN DEFICIENCIES.
Br J Cancer. 1964 Mar;18:98-101 PMID: 14154242

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1972.61

Published

1972-12-00

Pages

444-52

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2008667

Subset

External Links

PubMed source DOI: 10.1038/bjc.1972.61 PMC Full Text View journal details

Analysis Services

Iron metabolism in Hodgkin's disease.

Contact

WeChat Official Account