On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation.

Adenine Nucleotides/metabolism Chromatography, Thin Layer Coliphages/enzymology Cytosine Nucleotides/metabolism DNA Nucleotidyltransferases/metabolism,physiology DNA, Bacterial DNA, Viral/biosynthesis Deoxyribonucleotides/metabolism Escherichia coli/enzymology Exonucleases/metabolism Genes Guanine Nucleotides/metabolism Kinetics Mutation Phenotype Phosphorus Isotopes Species Specificity Structure-Activity Relationship Temperature Templates, Genetic Thymine Nucleotides/metabolism

Adenine Nucleotides Cytosine Nucleotides DNA, Bacterial DNA, Viral Deoxyribonucleotides Guanine Nucleotides Phosphorus Isotopes Thymine Nucleotides DNA Nucleotidyltransferases Exonucleases