Thymineless death in polA+ and polA- strains of Escherichia coli.

Journal of bacteriology ·Vol. 115 ·No. 2 ·1973-08-00 ·Pages 707-8

Berg CM, O'Neill JM

Abstract

The extreme sensitivity of polA(-) cells to thymineless death is due, primarily, to the absence of an extended lag prior to the commencement of death. Once thymineless death has commenced, the rate in polA(-) cells is only slightly faster than in polA(+) cells.

MeSH Terms

Culture Media DNA Nucleotidyltransferases/biosynthesis DNA Repair DNA, Bacterial/biosynthesis Escherichia coli/enzymology,growth & development,metabolism Methionine/metabolism Mutation Thiamine/metabolism Thymine/metabolism

Chemicals

Culture Media DNA, Bacterial Methionine DNA Nucleotidyltransferases Thymine Thiamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Berg C M

O'Neill J M

References (8)

8 references, click to expand

Isolation of an E. coli strain with a mutation affecting DNA polymerase.
Nature. 1969 Dec 20;224(5225):1164-6 PMID: 4902142
Thymineless death in Escherichia coli: deoxyribonucleic acid replication and the immune state.
J Bacteriol. 1970 Apr;102(1):106-17 PMID: 4908667
Auxotroph accumulation in deoxyribonucleic acid polymeraseless strains of Escherichia coli K-12.
J Bacteriol. 1971 Jun;106(3):797-801 PMID: 4934065
Thymine deficiency and the normal DNA replication cycle. I.
J Mol Biol. 1961 Apr;3:144-55 PMID: 13764647
Alkaline sucrose gradient sedimentation of chromosomal deoxyribonucleic acid from Escherichia coli PolA + and PolA - strains during thymine starvation.
J Bacteriol. 1971 Dec;108(3):1422-3 PMID: 4945202
Loss of deoxyribonucleic acid-thymine during thymine starvation of Escherichia coli.
J Bacteriol. 1972 Oct;112(1):646-8 PMID: 4562414
The induction of thymine synthesis by T2 infection of a thymine requiring mutant of Escherichia coli.
J Bacteriol. 1954 Jul;68(1):80-8 PMID: 13183905
Monofunctional alkylating agent-induced inactivation, mutagenesis and DNA degradation in an Escherichia coli mutant deficient in DNA polymerase.
Mol Gen Genet. 1971;111(4):357-67 PMID: 4936312

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.115.2.707-708.1973

Published

1973-08-00

Pages

707-8

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC246303

Subset

External Links

PubMed source DOI: 10.1128/jb.115.2.707-708.1973 PMC Full Text View journal details

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Thymineless death in polA+ and polA- strains of Escherichia coli.

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