Virulence of six strains of Mycobacterium bovis (BCG) in mice.

Infection and immunity ·Vol. 8 ·No. 5 ·1973-11-00 ·Pages 736-42

Sher NA, Chaparas SD, Pearson J, Chirigos M

Abstract

The abilities of six strains of Mycobacterium bovis strain BCG to replicate in vivo and to cause spleen enlargement in the CDF(1) male mouse were compared. The strains were grown in synthetic medium and harvested soon after complete pellicles were produced on liquid medium. In addition, two freeze-dried commercially available preparations were tested. The comparisons were made on the basis of injecting equal numbers of colony-forming units. Strain differences were marked. The Brazil strain was most effective in stimulating spleen enlargement, and the Japan strain was the least effective. This correlated with the number of colony-forming units isolated from the spleen.

MeSH Terms

Animals BCG Vaccine/isolation & purification Carmustine Male Mice Mycobacterium bovis/pathogenicity Organ Size Spleen/microbiology Virulence

Chemicals

BCG Vaccine Carmustine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Sher N A

Chaparas S D

Pearson J

Chirigos M

References (16)

16 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.8.5.736-742.1973

Published

1973-11-00

Pages

736-42

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC422920

Subset

External Links

PubMed source DOI: 10.1128/iai.8.5.736-742.1973 PMC Full Text View journal details

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Virulence of six strains of Mycobacterium bovis (BCG) in mice.

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