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PMID: 4584055 Published · ppublish English Journal Article

An ultrastructural analysis of Nocardia during experimental infections in mice.

Infection and immunity ·Vol. 8 ·No. 5 ·1973-11-00 ·Pages 828-40

Beaman BL

Abstract

Several strains of Nocardia that varied from virulent to avirulent were injected intraperitoneally into young mice. Histological and ultrastructural analysis of the resultant infections revealed that the bacteria and the lesions they induced were different depending upon the strain of organism used. Further, the morphological and tinctorial characteristics of the bacteria grown in vitro changes during growth in vivo. These observations strongly suggested that chemical and physical alterations occurred in the cell envelope of the Nocardia when grown in mice. Electron microscopy confirmed that significant structural modification occurred, especially in the cell envelope, when the nocardial cells established themselves within the host tissue. It was shown that the least virulent strain exhibited the most dramatic changes whereas the most virulent organism appeared to be affected the least.

MeSH Terms
Animals Bacteriological Techniques Female Kidney/microbiology Lung/microbiology Male Mice Microscopy, Electron Nocardia/cytology,pathogenicity Nocardia Infections/microbiology Pericardium/microbiology Peritoneal Cavity/microbiology Virulence
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Beaman B L
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23 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.8.5.828-840.1973
Published
1973-11-00
Pages
828-40
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422934
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.8.5.828-840.1973 PMC Full Text View journal details
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