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PMID: 4587601 Published · ppublish English Journal Article

Histidine regulation in Salmonella typhimurium. XV. Procedure for the selection of mutants unable to derepress the histidine operon.

Journal of bacteriology ·Vol. 117 ·No. 1 ·1974-01-00 ·Pages 116-25

Straus DS, Wyche JH

Abstract

A general search has been made for mutants defective in their ability to derepress the histidine operon. The procedure was to select for mutants with an increased sensitivity to the false feedback inhibitor, 2-thiazolealanine. Five mutant strains defective in derepression have been isolated. All five strains are unable to derepress normally because of mutations located in the operator-promoter region of the histidine operon.

MeSH Terms
Amino Acids, Sulfur/pharmacology Chromosome Mapping Culture Media Drug Resistance, Microbial Genes, Regulator Glucose/metabolism Histidine/biosynthesis Mutation Operon Salmonella typhimurium/drug effects,growth & development,isolation & purification,metabolism Stereoisomerism Transduction, Genetic Triazoles/pharmacology
Chemicals
Amino Acids, Sulfur Culture Media Triazoles Histidine Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Straus D S
Wyche J H
References (30)
30 references, click to expand
  1. Mutant strains of Escherichia coli K-12 exhibiting enhanced sensitivity to 5-methyltryptophan.
    J Bacteriol. 1972 Oct;112(1):93-101 PMID: 4404059
  2. [Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications].
    Nat New Biol. 1972 Jul 19;238(81):72-4 PMID: 4558263
  3. F + , Hfr, and F' strains of Salmonella typhimurium and Salmonella abony.
    Bacteriol Rev. 1972 Dec;36(4):608-37 PMID: 4568766
  4. Interference with the feed-back control of histidine biosynthesis.
    J Biol Chem. 1961 Aug;236:2261-7 PMID: 13773370
  5. Chromosomal alterations affecting the regulation of histidine biosynthetic enzymes in Salmonella.
    J Mol Biol. 1963 Jul;7:23-42 PMID: 14012567
  6. NON-INDUCIBLE MUTANTS OF THE REGULATOR GENE IN THE "LACTOSE" SYSTEM OF ESCHERICHIA COLI.
    J Mol Biol. 1964 Apr;8:582-92 PMID: 14153528
  7. EFFECT OF ALPHA-METHYLHISTIDINE ON THE CONTROL OF HISTIDINE SYNTHESIS.
    J Mol Biol. 1964 Sep;9:670-82 PMID: 14216610
  8. Cold-sensitive mutants of Escherichia coli resulting from increased feedback inhibition.
    Proc Natl Acad Sci U S A. 1965 Aug;54(2):451-7 PMID: 5324392
  9. Mode of action of the herbicide, 3-amino-1,2,4-triazole(amitrole): inhibition of an enzyme of histidine biosynthesis.
    Arch Biochem Biophys. 1965 Dec;112(3):544-7 PMID: 5326242
  10. Histidine regulatory mutants in Salmonella typhimurium. I. Isolation and general properties.
    J Mol Biol. 1966 Dec 28;22(2):305-23 PMID: 5339687
  11. Histidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase.
    J Mol Biol. 1966 Dec 28;22(2):325-33 PMID: 5339688
  12. Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.
    J Mol Biol. 1966 Dec 28;22(2):335-47 PMID: 5339689
  13. Translation and polarity in the histidine operon. 3. The isolation of prototrophic polar mutations.
    J Mol Biol. 1967 Nov 28;30(1):109-24 PMID: 4294870
  14. Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants.
    J Mol Biol. 1967 Nov 28;30(1):81-95 PMID: 4294871
  15. Histidine regulatory mutants in Salmonella typhiumium. VI. Dominance studies.
    J Mol Biol. 1968 May 14;33(3):547-57 PMID: 4302595
  16. The L-arabinose operon in Escherichia coli B-r: a genetic demonstration of two functional states of the product of a regulator gene.
    Proc Natl Acad Sci U S A. 1969 Apr;62(4):1100-7 PMID: 4894687
  17. Studies on repression of the histidine operon. II. The role of the first enzyme in control of the histidine system.
    Proc Natl Acad Sci U S A. 1969 Jun;63(2):481-8 PMID: 4895539
  18. Histidine regulation in Salmonella typhimurium. VII. Purification and general properties of the histidyl transfer ribonucleic acid synthetase.
    J Biol Chem. 1970 Apr 10;245(7):1710-6 PMID: 4985616
  19. Transcription initiation in the histidine operon of Salmonella typhimurium.
    Proc Natl Acad Sci U S A. 1970 Apr;65(4):925-32 PMID: 4909470
  20. Cyclic adenosine monophosphate in bacteria.
    Science. 1970 Jul 24;169(3943):339-44 PMID: 4317896
  21. Nonsense mutants in the regulator gene araC of the L-arabinose system of Escherichia coli B-r.
    Genetics. 1970 May;65(1):27-39 PMID: 4920896
  22. Mutations creating a new initiation point for expression of the histidine operon in Salmonella typhimurium.
    J Mol Biol. 1968 Jul 14;35(1):71-82 PMID: 4939780
  23. Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis.
    Proc Natl Acad Sci U S A. 1971 Sep;68(9):2258-62 PMID: 4332251
  24. Histidine regulation in Salmonella typhimurium. IX. Histidine transfer ribonucleic acid of the regulatory mutants.
    J Biol Chem. 1972 Feb 25;247(4):1080-8 PMID: 4551510
  25. Classification and mapping of spontaneous and induced mutations in the histidine operon of Salmonella.
    Adv Genet. 1971;16:1-34 PMID: 4947105
  26. Lac repressor-operator interaction. V. Characterization of super- and pseudo-wild-type repressors.
    J Mol Biol. 1972 Feb 28;64(1):181-99 PMID: 4552482
  27. Histidine regulation in Salmonella typhimurium. X. Kinetic studies of mutant histidyl transfer ribonucleic acid synthetases.
    J Biol Chem. 1972 Apr 25;247(8):2302-7 PMID: 4553439
  28. Histidine regulation in Salmonella typhimurium. 13. Nucleotide sequence of histidine transfer ribonucleic acid.
    J Biol Chem. 1972 May 25;247(10):2989-3000 PMID: 4337503
  29. Histidine regulation in Salmonella typhimurium. XI. The percentage of transfer RNA His charged in vivo and its relation to the repression of the histidine operon.
    J Mol Biol. 1972 Apr 28;66(1):131-42 PMID: 4339187
  30. Linkage map of Salmonella typhimurium, edition IV.
    Bacteriol Rev. 1972 Dec;36(4):558-86 PMID: 4568764
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.117.1.116-125.1974
Published
1974-01-00
Pages
116-25
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC246532
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.117.1.116-125.1974 PMC Full Text View journal details
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