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PMID: 4589889 Published · ppublish English Journal Article

Indirect ultraviolet-reactivation of phage lambda.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 1 ·1974-01-00 ·Pages 144-7

George J, Devoret R, Radman M

Abstract

When an F(-) recipient Escherichia coli K12 bacterium receives Hfr or F-lac(+) DNA from an ultraviolet-irradiated donor, its capacity to promote DNA repair and mutagenesis of ultraviolet-damaged phage lambda is substantially increased. We call this phenomenon indirect ultraviolet-reactivation, since its features are essentially the same as those of ultraviolet-reactivation; this repair process occurs in pyrimidine dimer excision-deficient strains and produces clear plaque mutations of the restored phage. Moreover, this process is similar to indirect ultraviolet-induction of prophage lambda, since it is promoted by conjugation. However, contrarily to indirect induction, it is produced by Hfr donors and occurs in recipients restricting the incoming ultraviolet-damaged donor DNA. The occurrence of indirect ultraviolet-reactivation provides evidence for the existence in E. coli of an inducible error-prone mechanism for the repair of DNA.

MeSH Terms
Coliphages/growth & development,radiation effects Conjugation, Genetic DNA Repair/radiation effects DNA, Viral/biosynthesis,radiation effects Escherichia coli/metabolism Lysogeny Mutation/radiation effects Ultraviolet Rays Viral Plaque Assay
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
George J
Devoret R
Radman M
References (27)
27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.71.1.144
Published
1974-01-00
Pages
144-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC387953
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.71.1.144 PMC Full Text View journal details
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