Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae.

Journal of bacteriology ·Vol. 117 ·No. 3 ·1974-03-00 ·Pages 1240-7

Sumrada R, Cooper TG

Abstract

Saccharomyces cerevisiae degrades allantoin in five steps to ammonia, CO(2), and glyoxylate. Previously we demonstrated that allophanic acid, the last intermediate of the pathway, was required for induction of all five degradative enzymes. The data presented here indicate that oxaluric acid, an allophanate analogue, is capable of serving as a non-metabolizable inducer. Oxaluric acid brings about a high level of induction even in strains lacking urea carboxylase. Induction observed with parabanic acid was found to result from its spontaneous breakdown to oxaluric acid.

MeSH Terms

Allantoin/metabolism Amides/metabolism,pharmacology Amidohydrolases/biosynthesis Ammonia/metabolism Carbamates/metabolism,pharmacology Chromatography, Gas Enzyme Induction Formamides/metabolism Hydantoins/metabolism Hydrolases/biosynthesis Ligases/biosynthesis Mutation Oxalates/metabolism,pharmacology Oxamic Acid/analogs & derivatives Saccharomyces cerevisiae/enzymology,metabolism Urea

Chemicals

Amides Carbamates Formamides Hydantoins Oxalates Allantoin oxaluric acid Ammonia Urea Hydrolases Amidohydrolases Ligases Oxamic Acid

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sumrada R

Cooper T G

References (10)

10 references, click to expand

An adenosine 3':5'-cyclic monophosphate-binding protein that acts on the transcription process.
Proc Natl Acad Sci U S A. 1971 Jan;68(1):215-8 PMID: 4322261
The properties and interrelationship of oxaluric and parabanic acids.
Arch Biochem Biophys. 1955 Jun;56(2):405-11 PMID: 14377591
Urea carboxylase and allophanate hydrolase. Two components of adenosine triphosphate:urea amido-lyase in Saccharomyces cerevisiae.
J Biol Chem. 1972 Mar 10;247(5):1349-53 PMID: 4551940
Induction of the allantoin degradative enzymes by allophanic acid, the last intermediate of the pathway.
Biochem Biophys Res Commun. 1973 May 1;52(1):137-42 PMID: 4576267
The induction of urea carboxylase and allophanate hydrolase in Saccharomyces cerevisiae.
J Biol Chem. 1973 Sep 10;248(17):6203-9 PMID: 4580053
Induction of the allantoin degradative enzymes in Saccharomyces cerevisiae by the last intermediate of the pathway.
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2340-4 PMID: 4599622
Phosphorolysis of carbamyl oxamic acid.
Biochim Biophys Acta. 1960 Dec 4;45:389-91 PMID: 13779744
Purification and DNA-binding properties of the catabolite gene activator protein.
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1222-5 PMID: 4331084
Mechanism of the allantoin fermentation.
J Biol Chem. 1962 Jul;237:2271-7 PMID: 13924343
OXAMIC TRANSCARBAMYLASE OF STREPTOCOCCUS ALLANTOICUS.
J Bacteriol. 1964 Jan;87:75-80 PMID: 14102876

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.117.3.1240-1247.1974

Published

1974-03-00

Pages

1240-7

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC246607

Subset

External Links

PubMed source DOI: 10.1128/jb.117.3.1240-1247.1974 PMC Full Text View journal details

Analysis Services

Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae.

Contact

WeChat Official Account