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PMID: 4595204 Published · ppublish English Journal Article

Studies on L-serine deaminase in Escherichia coli K-12.

Journal of bacteriology ·Vol. 118 ·No. 1 ·1974-04-00 ·Pages 53-8

Isenberg S, Newman EB

Abstract

l-Serine deaminase has been studied in toluene-treated cells of Escherichia coli K-12 and shown to be a discrete entity distinct from l-threonine deaminase. Its level in the cell varies as a function of nitrogen nutrition, carbon source, and amino acids (glycine and leucine). The metabolic role of the enzyme remains unclear but may be related to serine toxicity. The enzyme is unstable within the cell in the presence of its inducers, glycine and leucine, but not in their absence.

MeSH Terms
Amino Acids/metabolism Cell-Free System Deamination Drug Stability Escherichia coli/drug effects,enzymology,metabolism Hydro-Lyases/metabolism Hydrogen-Ion Concentration L-Serine Dehydratase/metabolism Mutation Nitrogen/metabolism Proline/metabolism Pyruvates/biosynthesis Serine/metabolism Stereoisomerism Succinates/metabolism Threonine/metabolism Toluene/pharmacology
Chemicals
Amino Acids Pyruvates Succinates Threonine Toluene Serine Proline Hydro-Lyases L-Serine Dehydratase Nitrogen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Isenberg S
Newman E B
References (24)
24 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.118.1.53-58.1974
Published
1974-04-00
Pages
53-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC246639
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.118.1.53-58.1974 PMC Full Text View journal details
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