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PMID: 4597116 Published · ppublish English Journal Article

Silver sulfadiazine: effect on the growth and metabolism of bacteria.

Antimicrobial agents and chemotherapy ·Vol. 2 ·No. 5 ·1972-11-00 ·Pages 367-72

Rosenkranz HS, Carr HS

Abstract

Even though the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. AgSu blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action. The ribosomes, ribonucleic acid, and DNA isolated from treated cells were normal qualitatively. Bacteria deficient in DNA polymerase were not more sensitive than their parent strain to the lethal action of AgSu. Radioactive AgSu was localized mainly in the cytoplasmic membrane fraction of treated cells.

MeSH Terms
Bacteria/drug effects,growth & development,metabolism Escherichia coli/growth & development Pseudomonas/growth & development Silver/pharmacology Sulfadiazine/pharmacology Tritium
Chemicals
Sulfadiazine Tritium Silver
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rosenkranz H S
Carr H S
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26 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.2.5.367
Published
1972-11-00
Pages
367-72
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444322
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.2.5.367 PMC Full Text View journal details
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