Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors.

Antimicrobial agents and chemotherapy ·Vol. 3 ·No. 2 ·1973-02-00 ·Pages 266-9

Brzezinska M, Davies J

Abstract

Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa.

MeSH Terms

Drug Resistance, Microbial Escherichia coli/enzymology,metabolism Extrachromosomal Inheritance Kanamycin/metabolism Neomycin/metabolism Phosphotransferases/metabolism

Chemicals

Kanamycin Phosphotransferases Neomycin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Brzezinska M

Davies J

References (9)

9 references, click to expand

R-factor mediated gentamicin resistance: A new enzyme which modifies aminoglycoside antibiotics.
FEBS Lett. 1971 May 20;14(5):293-296 PMID: 11945779
Properties of an R factor from Pseudomonas aeruginosa.
J Bacteriol. 1971 Dec;108(3):1244-9 PMID: 4945193
Studies on antibiotic SF-733. A new antibiotic. II. Chemical structure of antibiotic SF-733.
J Antibiot (Tokyo). 1970 Apr;23(4):173-83 PMID: 5423362
Structure determinations of enzymatically phosphorylated products of aminoglycosidic antibiotics by proton magnetic resonance.
J Antibiot (Tokyo). 1971 Dec;24(12):823-9 PMID: 4110867
The problems of drug-resistant pathogenic bacteria. R factors: biochemical mechanisms of resistance to aminoglycoside antibiotics.
Ann N Y Acad Sci. 1971 Jun 11;182:226-33 PMID: 4936664
Butirosin, a new aminoglycosidic antibiotic complex: isolation and characterization.
Antimicrob Agents Chemother. 1972 Aug;2(2):84-8 PMID: 4670491
Transfer of anibioic resistanceetween Pseudomonas aeruginosa, Escherichia coli, and other gram-negative bacilli in rns.
Lancet. 1971 Jan 23;1(7691):149-52 PMID: 4100077
Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors.
J Bacteriol. 1969 Nov;100(2):1144-6 PMID: 4902391
Transmissible multiple drug resistance in Enterobacteriaceae.
Science. 1972 May 19;176(4036):758-68 PMID: 5031472

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.3.2.266

Published

1973-02-00

Pages

266-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC444398

Subset

External Links

PubMed source DOI: 10.1128/AAC.3.2.266 PMC Full Text View journal details

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Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors.

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