The relative numbers of different genes in exponential microbial cultures.

Genetics ·Vol. 76 ·No. 3 ·1974-03-00 ·Pages 401-10

Painter PR

Abstract

It is shown that the results of the marker frequency analysis of Sueoka and Yoshikawa (1965) can be derived as very good approximations from a model where the rigid assumptions of their analysis are relaxed to take into account statistical variations in the timing of cell events. It is further shown that the expression for the amount of DNA per cell can be approximated by an elementary exponential function of the growth rate, and this result facilitates genetic mapping by DNA hybridization techniques. An analysis of recent data on gene frequencies in Escherichia coli corroborates a model of symmetric, bidirectional chromosome replication with a replication time of approximately thirty minutes.

MeSH Terms

Cell Division Chromosome Mapping Chromosomes DNA DNA Replication Escherichia coli Gene Frequency Genetics, Microbial Models, Biological Nucleic Acid Hybridization Time Factors

Chemicals

DNA

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Painter P R

References (13)

13 references, click to expand

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Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/76.3.401

Published

1974-03-00

Pages

401-10

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1213074

Subset

External Links

PubMed source DOI: 10.1093/genetics/76.3.401 PMC Full Text View journal details

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The relative numbers of different genes in exponential microbial cultures.

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