Malignant melanoma: specific immunity induced by bacillus Calmette-Guérin in BALB-c mice.

Science (New York, N.Y.) ·Vol. 185 ·No. 4145 ·1974-07-05 ·Pages 68-9

Faraci RP, Schour L

Abstract

Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells.

MeSH Terms

Animals Antibodies, Bacterial/analysis Antibodies, Neoplasm/analysis Antilymphocyte Serum BCG Vaccine Carcinoma/prevention & control Cell Line Cytotoxicity Tests, Immunologic Lymphocytes/immunology Mammary Neoplasms, Experimental/prevention & control Melanoma/immunology,prevention & control Methylcholanthrene Mice Mice, Inbred BALB C Mycobacterium bovis/immunology Neoplasm Transplantation Sarcoma, Experimental/chemically induced,prevention & control Transplantation, Homologous

Chemicals

Antibodies, Bacterial Antibodies, Neoplasm Antilymphocyte Serum BCG Vaccine Methylcholanthrene

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Faraci R P

Schour L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.185.4145.68

Published

1974-07-05

Pages

68-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.185.4145.68 View journal details

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Malignant melanoma: specific immunity induced by bacillus Calmette-Guérin in BALB-c mice.

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