Clustering of the genes for allantoin degradation in Saccharomyces cerevisiae.

Journal of bacteriology ·Vol. 119 ·No. 2 ·1974-08-00 ·Pages 461-8

Lawther RP, Riemer E, Chojnacki B, Cooper TG

Abstract

We have shown that allantoin degradation in Saccharomyces cerevisiae proceeds exclusively through the intermediate formation of allantoic acid, urea, and allophanic acid. The number of reactions between allantoic acid and urea, however, remains obscure owing to our inability to isolate a mutant defective in ureidoglycolate hydrolase. Structural genes for the enzymes, allantoinase (dal1) and allantoicase (dal2) are located on chromosome IX promixal to the centromere in the order dal1-dal2-lysl.

MeSH Terms

Allantoin/metabolism Amidohydrolases/biosynthesis Chromosome Mapping Diploidy Genes Genetic Complementation Test Genetic Linkage Heterozygote Hydrolases/biosynthesis Ligases/biosynthesis Lyases/biosynthesis Molecular Biology Mutation Saccharomyces cerevisiae/enzymology,metabolism Ureohydrolases/biosynthesis

Chemicals

Allantoin Hydrolases Amidohydrolases Ureohydrolases Lyases Ligases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lawther R P

Riemer E

Chojnacki B

Cooper T G

References (31)

31 references, click to expand

Ureidoglycolate synthetase of Streptococcus allantoicus. II. Properties of the enzyme and reaction equilibrium.
J Bacteriol. 1965 Dec;90(6):1531-6 PMID: 5854583
A cluster of genes controlling three enzymes in histidine biosynthesis in Saccharomyces cerevisiae.
Genetics. 1966 Mar;53(3):445-59 PMID: 5919326
Enzymatic degradation of ureidoglycine by Pseudomonas acidovorans.
Biochem Biophys Res Commun. 1970 Jun 5;39(5):976-82 PMID: 5423834
Allantoate and ureidoglycolate degradation by Pseudomonas aeruginosa.
Biochim Biophys Acta. 1967 Jan 11;132(1):115-26 PMID: 6030341
The induction of urea carboxylase and allophanate hydrolase in Saccharomyces cerevisiae.
J Biol Chem. 1973 Sep 10;248(17):6203-9 PMID: 4580053
Specificity of binding subsites of allantoicase.
Biochim Biophys Acta. 1969 Jul 8;185(1):186-97 PMID: 4978705
The mechanism of allantoin catabolism by yeast.
Arch Biochem Biophys. 1953 Jun;44(2):468-74 PMID: 13058403
The aerobic breakdown of uric acid by certain pseudomonads.
J Gen Microbiol. 1957 Aug;17(1):1-11 PMID: 13475666
Evidence for nonsense mutations in the arom gene cluster of Neurospora crassa.
Genetics. 1968 Sep;60(1):49-58 PMID: 5710960
The assay of yeast ureidoglycolatase.
Anal Biochem. 1966 Dec;17(3):413-22 PMID: 5965980
Assay, purification and properties of allantoicase from Candida utilis.
Arch Biochem Biophys. 1968 Jul;126(1):261-8 PMID: 5671067
Purification of allantoicase from Pseudomonas aeruginosa.
Antonie Van Leeuwenhoek. 1969;35(4):463-6 PMID: 4989534
Partial enzyme aggregates formed by pleiotropic mutants in the arom gene cluster of Neurospora crassa.
Proc Natl Acad Sci U S A. 1971 Jan;68(1):58-62 PMID: 5276302
Urea carboxylase and allophanate hydrolase. Two components of adenosine triphosphate:urea amido-lyase in Saccharomyces cerevisiae.
J Biol Chem. 1972 Mar 10;247(5):1349-53 PMID: 4551940
OXAMIC TRANSCARBAMYLASE OF STREPTOCOCCUS ALLANTOICUS.
J Bacteriol. 1964 Jan;87:75-80 PMID: 14102876
Reversible activation of allantoate amidohydrolase by acid-pretreatment and other properties of the enzyme.
Biochim Biophys Acta. 1966 Feb 14;113(2):277-91 PMID: 5328936
Streptococcus allantoicus and the Fermentation of Allantoin.
J Bacteriol. 1943 Sep;46(3):251-9 PMID: 16560697
Nonsense mutations affecting the his4 enzyme complex of yeast.
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1198-205 PMID: 5260920
Allantoate hydrolysis by allantoate amidohydrolase.
Arch Biochem Biophys. 1970 Jan;136(1):273-9 PMID: 5415952
The Detection of Linkage in Tetrad Analysis.
Genetics. 1953 Mar;38(2):187-97 PMID: 17247432
Induction of the allantoin degradative enzymes in Saccharomyces cerevisiae by the last intermediate of the pathway.
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2340-4 PMID: 4599622
Degradation of allantoin by Pseudomonas acidovorans.
Biochim Biophys Acta. 1966 Feb 14;113(2):292-301 PMID: 5942430
The mechanism of allantoin degradation by a Pseudomonas.
J Bacteriol. 1954 Nov;68(5):598-603 PMID: 13211565
A gene cluster in Nuerospora crassa coding for an aggregate of five aromatic synthetic enzymes.
Proc Natl Acad Sci U S A. 1967 Oct;58(4):1453-60 PMID: 5237879
Mechanism of the allantoin fermentation.
J Biol Chem. 1962 Jul;237:2271-7 PMID: 13924343
Purification and stability of the multienzyme complex encoded in the arom gene cluster of Neurospora crassa.
Biochim Biophys Acta. 1972 Nov 10;289(1):1-12 PMID: 4263953
ALLANTOINASE ASSAYS AND THEIR APPLICATION TO YEAST AND SOYBEAN ALLANTOINASES.
Arch Biochem Biophys. 1964 Dec;108:460-7 PMID: 14244686
Ureidoglycolate synthetase of Streptococcus allantoicus. I. Measurement of glyoxylate and enzyme purification.
J Bacteriol. 1965 Dec;90(6):1525-30 PMID: 5854582
Allantoicase and ureidoglycolase in Pseudomonas and Penicillium species.
Biochim Biophys Acta. 1966 May 5;118(2):387-95 PMID: 4960174
Urea carboxylase and allophanate hydrolase: two components of a multienzyme complex in Saccharomyces cerevisiae.
Biochem Biophys Res Commun. 1972 Oct 6;49(1):45-51 PMID: 4562164
Activation and inactivation of allantoate amindohydrolase.
Biochim Biophys Acta. 1967 May 16;139(1):162-8 PMID: 4962134

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.119.2.461-468.1974

Published

1974-08-00

Pages

461-8

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC245628

Subset

External Links

PubMed source DOI: 10.1128/jb.119.2.461-468.1974 PMC Full Text View journal details

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Clustering of the genes for allantoin degradation in Saccharomyces cerevisiae.

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