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PMID: 46049 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

Treatment of small-cell carcinoma of bronchus.

Lancet (London, England) ·Vol. 1 ·No. 7899 ·1975-01-18 ·Pages 129-32

Laing AH, Berry RJ, Newman CR, Smith P

Abstract

A randomised trial comparing radiotherapy with a multiple chemotherapy regimen in 68 patients with small cell carcinoma of bronchus is reported. Although overall survival was poor, radiotherapy resulted in significantly longer survival, better amelioration of symptoms, and less side-effects than chemotherapy. Patients achieving complete or partial remission on radiotherapy relapsed mainly with extrathoracic disease, in contradistinction to those treated with chemotherapy whose thoracic disease recurred.

MeSH Terms

Adult Age Factors Aged Antineoplastic Agents/therapeutic use Bronchial Neoplasms/drug therapy,mortality,radiotherapy,therapy Carcinoma/drug therapy,mortality,radiotherapy,therapy Clinical Trials as Topic Drug Therapy, Combination Evaluation Studies as Topic Follow-Up Studies Humans Middle Aged Nitrogen Mustard Compounds/therapeutic use Prednisolone/therapeutic use Procarbazine/therapeutic use Radiotherapy/adverse effects Radiotherapy Dosage Time Factors Vinblastine/therapeutic use

Chemicals

Antineoplastic Agents Nitrogen Mustard Compounds Procarbazine Vinblastine Prednisolone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Laing A H

Berry R J

Newman C R

Smith P

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(75)91428-2

Published

1975-01-18

Pages

129-32

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(75)91428-2 View journal details

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Treatment of small-cell carcinoma of bronchus.

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