Specific inhibition of ribosomal RNA synthesis in Escherichia coli by tetracycline.

Adenosine Triphosphate/metabolism Culture Media DNA, Bacterial Depression, Chemical Dose-Response Relationship, Drug Escherichia coli/drug effects,metabolism Magnesium/pharmacology Nucleic Acid Hybridization Phosphates/metabolism Phosphorus Radioisotopes RNA, Bacterial/biosynthesis RNA, Messenger/biosynthesis RNA, Ribosomal/biosynthesis Ribonucleotides/biosynthesis Tetracycline/pharmacology Time Factors Tritium Uridine/metabolism

Culture Media DNA, Bacterial Phosphates Phosphorus Radioisotopes RNA, Bacterial RNA, Messenger RNA, Ribosomal Ribonucleotides Tritium Adenosine Triphosphate Tetracycline Magnesium Uridine