Cellular immunoabsorbents in transplantation immunity. Specific in vitro deletion and recovery of mouse lymphoid cells sensitized against allogeneic tumors.
Mouse lymphoid cells, sensitized against tumor allografts, can be deprived of the immunoreactive cells by in vitro absorption with specific fibroblast monolayers. Populations of lymphocytes so depleted are less effective in retarding tumor growth in vivo and in lysing tumor cells in vitro. Moreover, the adsorbed immunoreactive cells can be recovered specifically and are subsequently efficient in inhibiting tumor growth in vivo and in killing tumor cells in vitro. Further evidence is presented for the suggestion that the destruction of target cells in vitro by sensitized lymphoid cells is truly representative of the mode of destruction of grafted cells in vivo.
17 references, click to expand
-
Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer.J Exp Med. 1955 Aug 1;102(2):157-77 PMID: 13242741
-
Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.Immunology. 1968 Feb;14(2):181-96 PMID: 4966657
-
Interaction of immune lymphocytes with the mixtures of target cells possessing selected specificities of the H-2 immunizing allele.Immunology. 1971 Apr;20(4):457-68 PMID: 5553067
-
Kinetic analysis of a graft reaction induced in cell culture.Immunology. 1969 Nov;17(5):723-40 PMID: 5352754
-
Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells.J Exp Med. 1969 Jan 1;129(1):23-36 PMID: 5782770
-
Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts.J Immunol. 1961 Feb;86:228-39 PMID: 13785862
-
In vitro induction of a heterograft reaction: immunological parameters of the sensitization of rat lymphocytes against mouse cells in vitro.Transplantation. 1971 Oct;12(4):237-48 PMID: 4398839
-
Cellular antibodies in kidney homotransplantation.J Immunol. 1960 Nov;85:516-22 PMID: 13707551
-
QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : I. RELATIONSHIP OF THE DEGREE OF DESTRUCTION OF HOMOLOGOUS TARGET CELLS TO THE NUMBER OF LYMPHOCYTES AND TO THE TIME OF CONTACT IN CULTURE AND CONSIDERATION OF THE EFFECTS OF ISOIMMUNE SERUM.J Exp Med. 1965 Jul 1;122(1):143-66 PMID: 19867293
-
QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS.Transplantation. 1965 May;3:423-31 PMID: 14285093
-
Tumor immunity: tumor suppression in vivo initiated by soluble products of specifically stimulated lymphocytes.Science. 1971 May 14;172(3984):729-31 PMID: 4324665
-
Passive immunity in mice against C57BL leukosis E.L. 4 by means of iso-immune serum.Cancer Res. 1956 May;16(4):338-43 PMID: 13316761
-
Lymphocytes as mediators of cellular immunity: destruction of homologous target cells in culture.Transplantation. 1967 Jul;5(4):Suppl:986-8 PMID: 6049783
-
The selective elimination of immunologically competent cells from bone marrow and lymphocyte cell mixtures. 3. In vitro test for detection of immunocompetent cells in fractionated mouse spleen cell suspensions and primate bone marrow suspensions.Transplantation. 1969 Oct;8(4):422-34 PMID: 4986654
-
Lymphocyte stimulation: selective destruction of cells during blastogenic response to transplantation antigens.Science. 1971 Apr 30;172(3982):490-2 PMID: 5102476
-
Specificity of allogeneic cell recognition by human lymphocytes in vitro.Science. 1971 Jun 25;172(3990):1350-2 PMID: 4397152
-
Graft reaction in tissue culture. II. Quantification of the lytic action on mouse fibroblasts by rat lymphocytes sensitized on mouse embryo monolayers.Immunology. 1969 May;16(5):643-57 PMID: 5787770
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
