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PMID: 46237 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Carrier-determined tolerance in vitro.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 1 Pt 1 ·1975-01-00 ·Pages 141-4

Galanaud P, Aldo-Benson M, Borel Y

Abstract

A primary immune response to normal BDF1 spleen cells was obtained in vitro to the T-independent antigen TNP-T4 coliphage. This anti-TNP response was suppressed by exposing the spleen cells for 6 hr to TNP bound either to isologous or heterologous gamma-globulin. The suppression was hapten specific. In contrast, TNP-albumin conjugates did not induce tolerance in vitro.

MeSH Terms

Animals Carrier Proteins Cattle/immunology Cells, Cultured Coliphages/immunology Erythrocytes/immunology Haptens Hemolytic Plaque Technique Humans Immune Tolerance Lymphocytes/immunology Male Mice Mice, Inbred DBA Nitrophenols/immunology Rabbits/immunology Serum Albumin, Bovine Sheep/immunology Spleen/cytology Thymus Gland/abnormalities gamma-Globulins

Chemicals

Carrier Proteins Haptens Nitrophenols gamma-Globulins Serum Albumin, Bovine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Galanaud P

Aldo-Benson M

Borel Y

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-01-00

Pages

141-4

Language

English

Region

United States

NLM ID

2985117R

Subset

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