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PMID: 4626405 Published · ppublish English Journal Article

Calcium-regulated parathyroid hormone peptidase.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 8 ·1972-08-00 ·Pages 2341-5

Fischer JA, Oldham SB, Sizemore GW, Arnaud CD

Abstract

An enzymatic activity that catalyzes the conversion of glandular parathyroid hormone to a smaller-molecular-weight, biologically and immunologically active form of this hormone has been extracted from normal parathyroid and other porcine tissues. The product of the conversion has the immunologic characteristics of the hormone that occurs in peripheral serum and in tissue culture medium from parathyroid explants. The enzyme is activated by chelating agents and is inhibited by high calcium concentrations, suggesting that this enzyme may be important in the regulation of secretion or metabolism of the hormone.

MeSH Terms
Animals Antigen-Antibody Complex/analysis Calcium/blood,metabolism,urine Chromatography, Gel Edetic Acid/pharmacology Electrophoresis, Disc Enzyme Activation/drug effects Hydrogen-Ion Concentration Iodine Isotopes Methods Molecular Weight Parathyroid Glands/enzymology,immunology Parathyroid Hormone/metabolism Peptide Hydrolases/isolation & purification,metabolism Radioimmunoassay Swine Temperature Tissue Extracts
Chemicals
Antigen-Antibody Complex Iodine Isotopes Parathyroid Hormone Tissue Extracts Edetic Acid Peptide Hydrolases Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fischer J A
Oldham S B
Sizemore G W
Arnaud C D
References (19)
19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.8.2341
Published
1972-08-00
Pages
2341-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC426930
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.8.2341 PMC Full Text View journal details
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