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PMID: 4629206 Published · ppublish English Journal Article

Physicochemical properties of Neisseria meningitidis group X polysaccharide antigen.

Infection and immunity ·Vol. 6 ·No. 5 ·1972-11-00 ·Pages 773-8

Apicella MA, Robinson JA

Abstract

Neisseria meningitidis group X occurs in human carrier populations and is rarely implicated in serious disease. This organism possesses a capsular group antigen which is an acidic polysaccharide. It is composed of the amino sugars, glucosamine, glucosamine-6-phosphate, galactosamine, and the simple hexose, glucose. The group X capsular antigen has an S(20,w) (0) of 3.6, and the acidic nature of the polysaccharide is reflected in an isoelectric point of 3.65. The meningococcal A, B, C, and Y polysaccharide group antigens are also composed primarily of amino sugars. The chemical composition of the group X antigen most closely resembles the capsular antigen of N. meningitidis group Y, which is also predominately a carrier organism.

MeSH Terms
Amino Acids/analysis Animals Antigens, Bacterial/analysis Carrier State/microbiology Chromatography, Gas Chromatography, Thin Layer Electrophoresis, Disc Endotoxins/analysis Hemagglutination Inhibition Tests Hemagglutination Tests Hexosamines/analysis Hexoses/analysis Humans Immune Sera Neisseria meningitidis/classification,immunology,isolation & purification Pentoses/analysis Polysaccharides, Bacterial/analysis Pronase/pharmacology Rabbits/immunology Trypsin/pharmacology
Chemicals
Amino Acids Antigens, Bacterial Endotoxins Hexosamines Hexoses Immune Sera Pentoses Polysaccharides, Bacterial Trypsin Pronase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Apicella M A
Robinson J A
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22 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.6.5.773-778.1972
Published
1972-11-00
Pages
773-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422609
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.6.5.773-778.1972 PMC Full Text View journal details
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