Long-term treatment of multiple sclerosis with azathioprine.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 36 ·No. 1 ·1973-02-00 ·Pages 124-6

Swinburn WR, Liversedge LA

Abstract

Nineteen patients with multiple sclerosis were treated with azathioprine for two years. There was no evidence that treatment prevented deterioration or reduced the number or severity of the relapses when compared with 24 control patients observed over the same period.

MeSH Terms

Azathioprine/administration & dosage,adverse effects,therapeutic use Blood Cell Count Blood Urea Nitrogen Brain Stem/drug effects Cerebellum/drug effects Evaluation Studies as Topic Humans Liver Function Tests Long-Term Care Multiple Sclerosis/drug therapy Pyramidal Tracts/drug effects Recurrence Urinary Bladder/drug effects Visual Acuity/drug effects

Chemicals

Azathioprine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Swinburn W R

Liversedge L A

References (7)

7 references, click to expand

Azathioprine therapy of "autoimmune" diseases.
Am J Med. 1966 Sep;41(3):404-12 PMID: 5330635
Long-term treatment of multiple sclerosis with corticotrophin.
Lancet. 1967 Aug 26;2(7513):429-31 PMID: 4166100
A preliminary evaluation of azathioprine (Imuran) in the treatment of multiple sclerosis.
Henry Ford Hosp Med J. 1969 Summer;17(2):89-92 PMID: 5783817
Multiple sclerosis: pilot therapeutic trial of immunosuppressants.
Schweiz Arch Neurol Neurochir Psychiatr. 1969;105(2):241-6 PMID: 4314087
[Immunosuppressive therapy of multiple sclerosis. 1. Preliminary communication on the results of treatment with azathioprine and anti-lymphocytic globulin].
Munch Med Wochenschr. 1971 Feb 12;113(7):221-31 PMID: 5107701
Therapeutic trial of Imuran (azathioprine) in multiple sclerosis.
Acta Neurol Scand. 1971;47(2):254-60 PMID: 4105313
On the evaluation of disability in multiple sclerosis.
Neurology. 1961 Aug;11:686-94 PMID: 13755335

Article Info

Journal

Journal of neurology, neurosurgery, and psychiatry

Abbr.

J Neurol Neurosurg Psychiatry

ISSN

0022-3050

DOI

10.1136/jnnp.36.1.124

Published

1973-02-00

Pages

124-6

Language

English

Region

England

NLM ID

2985191R

PMCID

PMC494286

Subset

External Links

PubMed source DOI: 10.1136/jnnp.36.1.124 PMC Full Text View journal details

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Long-term treatment of multiple sclerosis with azathioprine.

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