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PMID: 4632467 Published · ppublish English Journal Article

Recall of acquired cellular resistance in mice by antigens from killed Brucella.

Infection and immunity ·Vol. 5 ·No. 1 ·1972-01-00 ·Pages 42-7

Halliburton BL, Hinsdill RD

Abstract

Mice infected with Brucella abortus 19 were challenged intravenously with Listeria monocytogenes. Spleen assays to determine the number of viable Listeria cells present revealed that these mice were highly resistant to Listeria when challenged on day 17 of the Brucella infection. Resistance was absent in mice challenged on the 5th day and was declining in mice challenged on the 33rd day. Resistance could not be detected by day 49 of the Brucella infection but could be recalled by the injection of antigens from smooth B. abortus 2308. Thus, extracted antigens appeared to be as effective in recall as the live cells used in earlier studies. Similar injections of extracts from rough B. abortus 45/20, or from B. ovis REO 198, were also effective in recalling resistance; this suggests that the smooth surface agglutinogen may be relatively unimportant in recall.

MeSH Terms
Animals Antigens, Bacterial Brucella/immunology Brucella abortus/immunology Immunity, Cellular Listeria monocytogenes/immunology Mice Spleen/microbiology Staphylococcus/immunology Time Factors
Chemicals
Antigens, Bacterial
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Halliburton B L
Hinsdill R D
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.5.1.42-47.1972
Published
1972-01-00
Pages
42-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422318
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.5.1.42-47.1972 PMC Full Text View journal details
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