Initial effect of injury on ketone bodies and other blood metabolites.

Lancet (London, England) ·Vol. 1 ·No. 7897 ·1975-01-04 ·Pages 1-3

Smith R, Fuller DJ, Wedge JH, Williamson DH, Alberti KG

Abstract

The arterial and venous concentrations of ketone bodies and other metabolites were measured in twelve adults, from 2 to 24 hours after injury. Two groups could be distinguished, with or without hyperketonaemia (defined as more than 0.2 mmol per litre) in the 2-hour blood-sample. In the hyperdetonaemic group the concentrations of alanine, pyruvate, and lactate and the urinary nitrogen excretion were lower throughout the first 24 hours than in the non-hyperdetonaemic group. These preliminary results indicate that hyperketonaemia after trauma is associated with decreased protein breakdown.

MeSH Terms

Adolescent Adult Alanine/blood Blood Glucose/analysis Blood Specimen Collection Circadian Rhythm Colorimetry Craniocerebral Trauma/blood,complications,metabolism,urine Diabetes Complications Diabetes Mellitus/metabolism Fatty Acids, Nonesterified/blood Female Fractures, Bone/blood,complications,metabolism,urine Glutamates/blood Growth Hormone/blood Humans Insulin/blood Ketone Bodies/blood,metabolism Lactates/blood Male Middle Aged Nitrogen/urine Pyruvates/blood

Chemicals

Blood Glucose Fatty Acids, Nonesterified Glutamates Insulin Ketone Bodies Lactates Pyruvates Growth Hormone Nitrogen Alanine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Smith R

Fuller D J

Wedge J H

Williamson D H

Alberti K G

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(75)92369-7

Published

1975-01-04

Pages

1-3

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(75)92369-7 View journal details

Analysis Services

Initial effect of injury on ketone bodies and other blood metabolites.

Contact

WeChat Official Account