Ragweed hay fever: genetic control and linkage to HL-A haplotypes.

Science (New York, N.Y.) ·Vol. 178 ·No. 4066 ·1972-12-15 ·Pages 1201-3

Levine BB, Stember RH, Fotino M

Abstract

Clinical ragweed pollenosis (hay fever) and IgE antibody production specific for antigen E (the major purified protein antigen from ragweed pollen extract) correlated closely with HL-A haplotypes in successive generations of seven families. HL-A associated IgE antibody responsiveness was antigen specific and extended also to IgE antibody production. These data indicate an immune response (Ir) gene specific for antigen E necessary but not sufficient for the development of hay fever. This appears to be the first documentation of an Ir gene in man.

MeSH Terms

Adolescent Adult Allergens Antibody Formation Child Female Genetic Linkage Histocompatibility Antigens Humans Immunization Immunogenetics Immunoglobulin E Karyotyping Male Middle Aged Pedigree Pollen Rhinitis, Allergic, Seasonal/genetics,immunology Skin Tests

Chemicals

Allergens Histocompatibility Antigens Immunoglobulin E

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Levine B B

Stember R H

Fotino M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.178.4066.1201

Published

1972-12-15

Pages

1201-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.178.4066.1201 View journal details

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Ragweed hay fever: genetic control and linkage to HL-A haplotypes.

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