The in-vitro activity of tobramycin compared with that of other aminoglycosides.

Journal of clinical pathology ·Vol. 25 ·No. 11 ·1972-11-00 ·Pages 979-83

Waterworth PM

Abstract

The influence of medium composition, pH, serum, and magnesium on the action of tobramycin is compared to that on the action of gentamicin. The minimum inhibitory concentration of tobramycin, gentamicin, kanamycin, and streptomycin was determined for 472 strains including 19 species: tobramycin was found to be the most active against Ps. aeruginosa and kanamycin against Providence, but gentamicin was usually the most active against all other species. Ps. aeruginosa passaged on medium containing either gentamicin or tobramycin showed increased resistance to both. Sensitive strains of this species were shown to contain a small minority of cells resistant to these antibiotics, the presence of which is believed to account for the marked bactericidal synergy which was demonstrated between tobramycin and carbenicillin.

MeSH Terms

Amino Sugars/pharmacology Anti-Bacterial Agents/pharmacology Blood Carbenicillin/pharmacology Drug Synergism Gentamicins/pharmacology Glycosides/pharmacology Hydrogen-Ion Concentration Kanamycin/pharmacology Magnesium Microbial Sensitivity Tests Proteus/drug effects Salmonella/drug effects Shigella/drug effects Staphylococcus/drug effects Streptococcus/drug effects Streptomycin/pharmacology

Chemicals

Amino Sugars Anti-Bacterial Agents Gentamicins Glycosides Kanamycin Carbenicillin Magnesium Streptomycin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Waterworth P M

References (10)

10 references, click to expand

Dosage of gentamicin for pseudomonas infections.
Br Med J. 1967 May 27;2(5551):535-7 PMID: 6023986
Nebramycin, a new broad-spectrum antibiotic complex. I. Detection and biosynthesis.
Antimicrob Agents Chemother (Bethesda). 1967;7:314-23 PMID: 5596154
Nebramycin, a new broad-spectrum antibiotic complex. II. Description of Streptomyces tenebrarius.
Antimicrob Agents Chemother (Bethesda). 1967;7:324-31 PMID: 5596155
Nebramycin, a new broad-spectrum antibiotic complex. 3. Isolation and chemical-physical properties.
Antimicrob Agents Chemother (Bethesda). 1967;7:332-40 PMID: 5596156
Nebramycin, a new broad-spectrum antibiotic complex. IV. In vitro and in vivo laboratory evaluation.
Antimicrob Agents Chemother (Bethesda). 1967;7:341-8 PMID: 5596157
Combined action of carbenicillin and gentamicin on Pseudomonas aeruginosa in vitro.
Appl Microbiol. 1969 Jun;17(6):893-6 PMID: 4978927
Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin.
J Clin Pathol. 1969 Sep;22(5):534-8 PMID: 4983355
Preclinical assessment of the antibacterial activity of nebramycin factor 6.
Antimicrob Agents Chemother (Bethesda). 1970;10:322-7 PMID: 4939737
Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa.
Appl Microbiol. 1971 Dec;22(6):1147-51 PMID: 5002900
Evaluation of the in vitro activity of tobramycin as compared with that of gentamicin sulfate.
Appl Microbiol. 1972 Jan;23(1):4-7 PMID: 4621796

Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.25.11.979

Published

1972-11-00

Pages

979-83

Language

English

Region

England

NLM ID

0376601

PMCID

PMC477579

Subset

External Links

PubMed source DOI: 10.1136/jcp.25.11.979 PMC Full Text View journal details

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The in-vitro activity of tobramycin compared with that of other aminoglycosides.

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