A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.

British journal of pharmacology ·Vol. 46 ·No. 4 ·1972-12-00 ·Pages 764-6

Henderson G, Hughes J, Kosterlitz HW

Abstract

The isolated mouse vas deferens possesses an adrenergic excitatory motor innervation which can be inhibited by low concentrations of morphine (ID50=0.5 muM). This effect of morphine is mediated by specific receptors which are blocked by naloxone. Activation of the morphine receptors inhibits noradrenaline release. It is concluded that adrenergic neurotransmission in the mouse vas deferens differs in some important way from that at the more common, morphine-insensitive, adrenergic junctions.

MeSH Terms

Animals Electric Stimulation In Vitro Techniques Male Mice Morphine/administration & dosage,pharmacology Motor Neurons/drug effects Naloxone/pharmacology Neuroeffector Junction/drug effects Norepinephrine/analysis,antagonists & inhibitors Phentolamine/pharmacology Receptors, Adrenergic/drug effects Vas Deferens/drug effects

Chemicals

Receptors, Adrenergic Naloxone Morphine Norepinephrine Phentolamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Henderson G

Hughes J

Kosterlitz H W

References (6)

6 references, click to expand

3 H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens.
Acta Physiol Scand Suppl. 1971;371:1-18 PMID: 4402149
Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens.
Br J Pharmacol. 1972 Mar;44(3):472-91 PMID: 4339251
The effects of hexamethonium, morphine and adrenaline on the output of acetylcholine from the myenteric plexus-longitudinal muscle preparation of the ileum.
Br J Pharmacol. 1970 Nov;40(3):553P-554P PMID: 5497815
The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.
Br J Pharmacol Chemother. 1957 Mar;12(1):119-27 PMID: 13413163
Effect of morphine on some sympathetically innervated effectors.
Br J Pharmacol Chemother. 1961 Dec;17:539-51 PMID: 13875617
The action of morphine on the superior cervical ganglion and on the nictitating membrane of the cat.
Br J Pharmacol Chemother. 1957 Mar;12(1):79-85 PMID: 13413156

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1972.tb06901.x

Published

1972-12-00

Pages

764-6

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1666368

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1972.tb06901.x PMC Full Text View journal details

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A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.

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