Chemotherapeutic drugs increase killing of tumor cells by antibody and complement.

Science (New York, N.Y.) ·Vol. 188 ·No. 4183 ·1975-04-04 ·Pages 55-7

Segerling M, Ohanian SH, Borsos T

Abstract

When the ascitic forms of two antigenically distinct guinea pig hepatomas induced by diethylnitrosamine are treated in vitro with chemotherapeutic drugs, their sensitivity to killing by xenogeneic antibody plus guinea pig complement increases. The effect is dependent on drug dose, is reversible, and does not appear to be due to increased antigen expression or fixation of the early acting components of guinea pig complement.

MeSH Terms

Animals Antigen-Antibody Reactions/drug effects Antineoplastic Agents/pharmacology Azacitidine/pharmacology Carcinoma, Hepatocellular/chemically induced,immunology Cell Line Complement System Proteins Cyclophosphamide/pharmacology Cytarabine/pharmacology Fluorouracil/pharmacology Guinea Pigs Liver Neoplasms Methotrexate/pharmacology Neoplasms, Experimental/chemically induced,immunology Nitrosamines Vincristine/pharmacology

Chemicals

Antineoplastic Agents Nitrosamines Cytarabine Vincristine Cyclophosphamide Complement System Proteins Azacitidine Fluorouracil Methotrexate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Segerling M

Ohanian S H

Borsos T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.46622

Published

1975-04-04

Pages

55-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.46622 View journal details

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Chemotherapeutic drugs increase killing of tumor cells by antibody and complement.

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